Full Text:   <2330>

CLC number: R544.1

On-line Access: 2010-08-02

Received: 2010-06-18

Revision Accepted: 2010-07-01

Crosschecked: 2010-07-06

Cited: 5

Clicked: 5895

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.8 P.592-598

http://doi.org/10.1631/jzus.B1001010


Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome


Author(s):  Li-jiang Tang, Jian-jun Jiang, Xiao-feng Chen, Jian-an Wang, Xian-fang Lin, Yu-xi Du, Cong-feng Fang, Zhao-xia Pu

Affiliation(s):  Department of Cardiology, Taizhou Hospital, Wenzhou Medical College, Taizhou 317000, China, Department of Cardiology; more

Corresponding email(s):   jian_an_wang@yahoo.com

Key Words:  Aortic root, Uric acid, Hypertension, Metabolic syndrome


Li-jiang Tang, Jian-jun Jiang, Xiao-feng Chen, Jian-an Wang, Xian-fang Lin, Yu-xi Du, Cong-feng Fang, Zhao-xia Pu. Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome[J]. Journal of Zhejiang University Science B, 2010, 11(8): 592-598.

@article{title="Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome",
author="Li-jiang Tang, Jian-jun Jiang, Xiao-feng Chen, Jian-an Wang, Xian-fang Lin, Yu-xi Du, Cong-feng Fang, Zhao-xia Pu",
journal="Journal of Zhejiang University Science B",
volume="11",
number="8",
pages="592-598",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1001010"
}

%0 Journal Article
%T Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome
%A Li-jiang Tang
%A Jian-jun Jiang
%A Xiao-feng Chen
%A Jian-an Wang
%A Xian-fang Lin
%A Yu-xi Du
%A Cong-feng Fang
%A Zhao-xia Pu
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 8
%P 592-598
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1001010

TY - JOUR
T1 - Relation of uric acid levels to aortic root dilatation in hypertensive patients with and without metabolic syndrome
A1 - Li-jiang Tang
A1 - Jian-jun Jiang
A1 - Xiao-feng Chen
A1 - Jian-an Wang
A1 - Xian-fang Lin
A1 - Yu-xi Du
A1 - Cong-feng Fang
A1 - Zhao-xia Pu
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 8
SP - 592
EP - 598
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1001010


Abstract: 
Objective: uric acid (UA) is considered to be a powerful predictor of cardiovascular risk and hyperuricemia might be involved in the metabolic syndrome (MS). This study aims to investigate the relation between UA levels and aortic root dilatation. Methods: A total of 348 hypertensive patients [age (67.5±9.8) years] with or without MS were included in the study. The aortic root diameters at the aortic annulus, the sinuses of Valsalva, the sinotubular junction, and the proximal part of the ascending aorta were measured using a two-dimensional (2D) echocardiography. Serum UA levels were also measured for all patients. Results: A high UA level is independently associated with aortic root diameters at the sinuses of Valsalva (P=0.001) and the proximal ascending aorta (P<0.0001) in the hypertensive patients without MS. In contrast, aortic root diameters were not significantly related to UA levels in the hypertensive patients with MS. Furthermore, increased UA levels were associated with an increased risk for aortic root dilatation in the patients without MS (sex-adjusted hazard ratio 1.75, 95% confidence intervals (CI) 1.27–2.41), but not in those with MS. Conclusions: This study demonstrated an independent relationship between the aortic root dimensions and increased levels of serum UA in the hypertensive patients without MS. Further understanding of the mechanisms underlying these associations may allow a clearer interpretation of the potential value of specific urate-lowering treatment on cardiovascular disease.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Coats, A.J., 2009. Ethical authorship and publishing. International Journal of Cardiology, 131(2):149-150.

[2]Cuspidi, C., Meani, S., Fusi, V., Valerio, C., Sala, C., Zanchetti, A., 2006. Prevalence and correlates of aortic root dilatation in patients with essential hypertension: relationship with cardiac and extracardiac target organ damage. Journal of Hypertension, 24(3):573-580.

[3]Cuspidi, C., Meani, S., Valerio, C., Esposito, A., Sala, C., Maisaidi, M., Zanchetti, A., Mancia, G., 2007. Ambulatory blood pressure, target organ damage and aortic root size in never-treated essential hypertensive patients. Journal of Human Hypertension, 21(7):531-538.

[4]Eisenberg, M.J., Rice, S.A., Paraschos, A., Caputo, G.R., Schiller, N.B., 1993. The clinical spectrum of patients with aneurysms of the ascending aorta. American Heart Journal, 125(5):1380-1385.

[5]Gardin, J.M., Arnold, A.M., Polak, J., Jackson, S., Smith, V., Gottdiener, J., 2006. Usefulness of aortic root dimension in persons > or = 65 years of age in predicting heart failure, stroke, cardiovascular mortality, all-cause mortality and acute myocardial infarction (from the Cardiovascular Health Study). The American Journal of Cardiology, 97(2):270-275.

[6]Habashi, J.P., Judge, D.P., Holm, T.M., Cohn, R.D., Loeys, B.L., Cooper, T.K., Myers, L., Klein, E.C., Liu, G., Calvi, C., et al., 2006. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science, 312(5770):117-121.

[7]Hjortnaes, J., Algra, A., Olijhoek, J., Huisman, M., Jacobs, J., van der Graaf, Y., Visseren, F., 2007. Serum uric acid levels and risk for vascular diseases in patients with metabolic syndrome. The Journal of Rheumatology, 34(9):1882-1887.

[8]Ishizaka, N., Ishizaka, Y., Toda, E., Nagai, R., Yamakado, M., 2005. Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals. Arteriosclerosis Thrombosis and Vascular Biology, 25(5):1038-1044.

[9]Johnson, R.J., Kang, D.H., Feig, D., Kivlighn, S., Kanellis, J., Watanabe, S., Tuttle, K.R., Rodriguez-Iturbe, B., Herrera-Acosta, J., Mazzali, M., 2003. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension, 41(6):1183-1190.

[10]Karakaya, O., Barutcu, I., Esen, A.M., Dogan, S., Saglam, M., Karapinar, H., Akgun, T., Karavelioglu, Y., Esen, O., Ozdemir, N., et al., 2006. Relationship between circulating plasma matrix metalloproteinase-9 (gelatinase-B) concentration and aortic root dilatation. American Journal of Hypertension, 19(4):361-365.

[11]Kim, M., Roman, M.J., Cavallini, M.C., Schwartz, J.E., Pickering, T.G., Devereux, R.B., 1996. Effect of hypertension on aortic root size and prevalence of aortic regurgitation. Hypertension, 28(1):47-52.

[12]Lu, H., Rateri, D.L., Cassis, L.A., Daugherty, A., 2008. The role of the renin-angiotensin system in aortic aneurysmal diseases. Current Hypertension Reports, 10(2):99-106.

[13]Roman, M.J., Devereux, R.B., Niles, N.W., Hochreiter, C., Kligfield, P., Sato, N., Spitzer, M.C., Borer, J.S., 1987. Aortic root dilatation as a cause of isolated, severe aortic regurgitation. Prevalence, clinical and echocardiographic patterns, and relation to left ventricular hypertrophy and function. Annals of Internal Medicine, 106(6):800-807.

[14]Roman, M.J., Devereux, R.B., Kramer-Fox, R., O'Loughlin, J., 1989. Two-dimensional echocardiographic aortic root dimensions in normal children and adults. The American Journal of Cardiology, 64(8):507-512.

[15]Saito, I., Saruta, T., Kondo, K., Nakamura, R., Oguro, T., Yamagami, K., Ozawa, Y., Kato, E., 1978. Serum uric acid and the renin-angiotensin system in hypertension. Journal of the American Geriatrics Society, 26(6):241-247.

[16]Sanchez-Lozada, L.G., Tapia, E., Avila-Casado, C., Soto, V., Franco, M., Santamaria, J., Nakagawa, T., Rodriguez-Iturbe, B., Johnson, R.J., Herrera-Acosta, J., 2002. Mild hyperuricemia induces glomerular hypertension in normal rats. American Journal of Physiology-Renal Physiology, 283(5):F1105-F1110.

[17]Sui, X., Church, T.S., Meriwether, R.A., Lobelo, F., Blair, S.N., 2008. Uric acid and the development of metabolic syndrome in women and men. Metabolism, 57(6):845-852.

[18]Tan, C.E., Ma, S., Wai, D., Chew, S.K., Tai, E.S., 2004. Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians? Diabetes Care, 27(5):1182-1186.

[19]Verdecchia, P., Schillaci, G., Reboldi, G., Santeusanio, F., Porcellati, C., Brunetti, P., 2000. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study. Hypertension, 36(6):1072-1078.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE