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On-line Access: 2011-08-02

Received: 2011-06-30

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Crosschecked: 2011-06-30

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.8 P.660-667


Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease

Author(s):  Chun-na Jin, Hong Ma, Yan Lin, Jian-an Wang, Mei-xiang Xiang

Affiliation(s):  Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China, Cardiovascular Key Lab of Zhejiang Province, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   xiangmx@yahoo.com

Key Words:  Coronary heart disease, CMA1, Serum immunoglobulin E (IgE), Serum chymase

Chun-na Jin, Hong Ma, Yan Lin, Jian-an Wang, Mei-xiang Xiang. Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease[J]. Journal of Zhejiang University Science B, 2011, 12(8): 660-667.

@article{title="Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease",
author="Chun-na Jin, Hong Ma, Yan Lin, Jian-an Wang, Mei-xiang Xiang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease
%A Chun-na Jin
%A Hong Ma
%A Yan Lin
%A Jian-an Wang
%A Mei-xiang Xiang
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 8
%P 660-667
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1101008

T1 - Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease
A1 - Chun-na Jin
A1 - Hong Ma
A1 - Yan Lin
A1 - Jian-an Wang
A1 - Mei-xiang Xiang
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 8
SP - 660
EP - 667
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1101008

Objective: The gene for mast cell chymase (CMA1) is an ideal candidate for investigating the genetic predisposition to coronary heart disease (CHD), as activated mast cells have been found to be present in a greater proportion in the shoulder region of atheroma than in normal coronary intimae. Previous studies have indicated that CMA1 promoter polymorphism rs1800875 may be involved in regulating immunoglobulin E (IgE) levels in patients with eczema, and it is associated with the progression of immunoglobulin A nephropathy. Methods: The association between single nucleotide polymorphism (SNP) rs1800875, serum chymase, and serum IgE levels was examined in 175 CHD subjects and 95 non-CHD subjects. Results: Statistical analysis indicated no significant difference in allele frequency between CHD and non-CHD. However, a significant association was found between CMA1 genotypes and total IgE levels in CHD subjects. Meanwhile, crossover analysis revealed that, in GG homozygotes, CHD risk was nearly six times higher in those with IgE (U/ml) level <2.58 (natural logarithm conversion), while no association was found with chymase level. Conclusions: Polymorphism rs1800875 of CMA1 may be associated with serum IgE level in CHD subjects, but not with chymase level in both groups. In GG homozygotes, high IgE level is a protective factor against coronary disease.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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