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CLC number: R751.05

On-line Access: 2012-09-04

Received: 2012-04-22

Revision Accepted: 2012-08-09

Crosschecked: 2012-08-20

Cited: 5

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.9 P.745-750


Topical imiquimod treatment of cutaneous vascular disorders in pediatric patients: clinical evaluation on the efficacy and safety

Author(s):  Xiao-hong Mao, Jian-you Wang, Jian-liang Yan

Affiliation(s):  Department of Dermatology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   wangjianyou@medmail.com.cn

Key Words:  Infantile hemangioma (IH), Nevus flammeus (NF), Imiquimod, Treatment

Xiao-hong Mao, Jian-you Wang, Jian-liang Yan. Topical imiquimod treatment of cutaneous vascular disorders in pediatric patients: clinical evaluation on the efficacy and safety[J]. Journal of Zhejiang University Science B, 2012, 13(9): 745-750.

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author="Xiao-hong Mao, Jian-you Wang, Jian-liang Yan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Topical imiquimod treatment of cutaneous vascular disorders in pediatric patients: clinical evaluation on the efficacy and safety
%A Xiao-hong Mao
%A Jian-you Wang
%A Jian-liang Yan
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 9
%P 745-750
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200120

T1 - Topical imiquimod treatment of cutaneous vascular disorders in pediatric patients: clinical evaluation on the efficacy and safety
A1 - Xiao-hong Mao
A1 - Jian-you Wang
A1 - Jian-liang Yan
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 9
SP - 745
EP - 750
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200120

Objective: To evaluate the clinical effect of topical imiquimod treatment on cutaneous vascular disorders in pediatric patients. Methods: A retrospective investigation was conducted in 25 pediatric patients with cutaneous vascular disorders, including 19 infantile hemangiomas (IHs) (12 superficial/7 mixed type), 5 nevus flammeus (NF), and 1 pyogenic granuloma (PG). imiquimod 5% cream was applied every other day for 4 to 16 weeks (average 9.6 weeks). Results: Of the 19 IHs treated, an overall efficacy of 52.6% was achieved, with a clinical resolution rate of 15.8%, excellent rate of 26.3%, and moderate rate of 10.5%. The superficial type responded the best at 66.7%, while the mixed type showed only 28.6% effectiveness, which was predominantly from their superficial parts. No obvious response was noted in the 5 patients with NF. Side effects were observed in 78.9% of the patients, mostly mild to moderate local irritations and occasionally severe reactions such as thick crusting and ulceration. Systemic side events were observed in 4 IH patients including fever and digestive tract reactions. No recurrence was observed during the follow-up examination. Conclusions: Topical imiquimod could be an alternative option for the treatment of uncomplicated superficial IHs with satisfactory tolerability.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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