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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.5 P.359-371


Long-term follow-up of children conceived through assisted reproductive technology

Author(s):  Yue-hong Lu, Ning Wang, Fan Jin

Affiliation(s):  Key Laboratory of Reproductive Genetics (Zhejiang), Ministry of Education, and Centre of Reproductive Medicine, Womens Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; more

Corresponding email(s):   jinfan@zju.edu.cn

Key Words:  Assisted reproductive technologies (ART), Children, Follow-up

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Yue-hong Lu, Ning Wang, Fan Jin. Long-term follow-up of children conceived through assisted reproductive technology[J]. Journal of Zhejiang University Science B, 2013, 14(5): 359-371.

@article{title="Long-term follow-up of children conceived through assisted reproductive technology",
author="Yue-hong Lu, Ning Wang, Fan Jin",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Long-term follow-up of children conceived through assisted reproductive technology
%A Yue-hong Lu
%A Ning Wang
%A Fan Jin
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 5
%P 359-371
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%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200348

T1 - Long-term follow-up of children conceived through assisted reproductive technology
A1 - Yue-hong Lu
A1 - Ning Wang
A1 - Fan Jin
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 5
SP - 359
EP - 371
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200348

children conceived via assisted reproductive technologies (ART) are nowadays a substantial proportion of the population. It is important to follow up these children and evaluate whether they have elevated health risks compared to naturally conceived (NC) children. In recent years there has been a lot of work in this field. This review will summarize what is known about the health of ART-conceived children, encompassing neonatal outcomes, birth defects, growth and gonadal developments, physical health, neurological and neurodevelopmental outcomes, psychosocial developments, risk for cancer, and epigenetic abnormalities. Most of the children conceived after ART are normal. However, there is increasing evidence that ART-conceived children are at higher risk of poor perinatal outcome, birth defects, and epigenetic disorders, and the mechanism(s) leading to these changes have not been elucidated. Continuous follow-up of children after ART is of great importance as they progress through adolescence into adulthood, and new ART techniques are constantly being introduced.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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