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CLC number: R743.3

On-line Access: 2012-08-01

Received: 2012-06-08

Revision Accepted: 2012-06-26

Crosschecked: 2012-06-27

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.8 P.652-662


Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies

Author(s):  Li Shen, Liu-guang Song, Hong Ma, Chun-na Jin, Jian-an Wang, Mei-xiang Xiang

Affiliation(s):  Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   xiangmx@yahoo.com

Key Words:  Tea, Stroke, Prospective studies, Dose-response meta-analysis

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Li Shen, Liu-guang Song, Hong Ma, Chun-na Jin, Jian-an Wang, Mei-xiang Xiang. Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies[J]. Journal of Zhejiang University Science B, 2012, 13(8): 652-662.

@article{title="Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies",
author="Li Shen, Liu-guang Song, Hong Ma, Chun-na Jin, Jian-an Wang, Mei-xiang Xiang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies
%A Li Shen
%A Liu-guang Song
%A Hong Ma
%A Chun-na Jin
%A Jian-an Wang
%A Mei-xiang Xiang
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 8
%P 652-662
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1201001

T1 - Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies
A1 - Li Shen
A1 - Liu-guang Song
A1 - Hong Ma
A1 - Chun-na Jin
A1 - Jian-an Wang
A1 - Mei-xiang Xiang
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 8
SP - 652
EP - 662
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1201001

Objective: To determine the association between tea consumption and the risk of stroke. Methods: We searched the PubMed database from January 1966 to March 2012 and reviewed reference lists of retrieved articles to identify relevant studies. Studies were included if they reported relative risks (RRs) and corresponding 95% confidence intervals (CIs) of stroke with respect to three or more categories of tea consumption. A random-effects model was used to combine the study-specific risk estimates. Results: Fourteen studies, consisting of 513804 participants with a median follow-up of 11.5 years, were included in this meta-analysis. We observed a modest but statistically significant inverse association between tea consumption and risk of stroke. An increase of three cups/d in tea consumption was associated with a 13% decreased risk of stroke (RR 0.87; 95% CI, 0.81–0.94). The decreased risk of stroke with tea consumption was consistent among most subgroups. Based on the three studies that provided results for stroke subtypes, tea consumption was also inversely associated with the risk of ischemic stroke (RR 0.76; 95% CI, 0.69–0.84), but not cerebral hemorrhage (RR 0.96; 95% CI, 0.82–1.11) or subarachnoid hemorrhage (RR 0.81; 95% CI, 0.57–1.16). Conclusions: tea consumption is associated with a decreased risk of stroke, particularly ischemic stroke. More well-designed, rigorously conducted studies are needed in order to make confident conclusions about the association between tea consumption and stroke subtypes.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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