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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.11 P.993-1003


In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft

Author(s):  D. Burcu Hazer, Ercan Bal, Gülay Nurlu, Kemal Benli, Serdar Balci, Feral Öztürk, Baki Hazer

Affiliation(s):  Department of Neurosurgery, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla 48000, Turkey; more

Corresponding email(s):   burcuhazer@hotmail.com

Key Words:  Axonal spurting, Biodegradable polymer, Neuroregeneration, Nerve grafting

D. Burcu Hazer, Ercan Bal, Gülay Nurlu, Kemal Benli, Serdar Balci, Feral Öztürk, Baki Hazer. In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft[J]. Journal of Zhejiang University Science B, 2013, 14(11): 993-1003.

@article{title="In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft",
author="D. Burcu Hazer, Ercan Bal, Gülay Nurlu, Kemal Benli, Serdar Balci, Feral Öztürk, Baki Hazer",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft
%A D. Burcu Hazer
%A Ercan Bal
%A Gülay Nurlu
%A Kemal Benli
%A Serdar Balci
%A Feral Öztürk
%A Baki Hazer
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 11
%P 993-1003
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300016

T1 - In vivo application of poly-3-hydroxyoctanoate as peripheral nerve graft
A1 - D. Burcu Hazer
A1 - Ercan Bal
A1 - Gülay Nurlu
A1 - Kemal Benli
A1 - Serdar Balci
A1 - Feral Öztürk
A1 - Baki Hazer
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 11
SP - 993
EP - 1003
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300016

Objective: This study aims to investigate the degree of biocompatibility and neuroregeneration of a polymer tube, poly-3-hydroxyoctanoate (PHO) in nerve gap repair. Methods: Forty Wistar Albino male rats were randomized into two groups: autologous nerve gap repair group and PHO tube repair group. In each group, a 10-mm right sciatic nerve defect was created and reconstructed accordingly. neuroregeneration was studied by sciatic function index (SFI), electromyography, and immunohistochemical studies on Days 7, 21, 45 and 60 of implantation. Biocompatibility was analyzed by the capsule formation around the conduit. Biodegradation was analyzed by the molecular weight loss in vivo. Results: Electrophysiological and histomorphometric assessments demonstrated neuroregeneration in both groups over time. In the experimental group, a straight alignment of the Schwann cells parallel to the axons was detected. However, autologous nerve graft seems to have a superior neuroregeneration compared to PHO grafts. Minor biodegradation was observed in PHO conduit at the end of 60 d. Conclusions: Although neuroregeneration is detected in PHO grafts with minor degradation in 60 d, autologous nerve graft is found to be superior in axonal regeneration compared to PHO nerve tube grafts. PHO conduits were found to create minor inflammatory reaction in vivo, resulting in good soft tissue response.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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