Full Text:
<2706>
Summary: 
<2076>
CLC number: R736.1
On-line Access: 2014-12-03
Received: 2014-04-30
Revision Accepted: 2014-08-12
Crosschecked: 2014-11-14
Cited: 0
Clicked: 5407
Citations: Bibtex RefMan EndNote GB/T7714
Management of differentiated thyroid carcinoma with bone metastasis: a case report and review of the Chinese literature
| ||||||||||||||
Wei-dong Zhang, Da-ren Liu, Cheng-cheng Feng, Chuan-biao Zhou, Chen-ni Zhan, Ri-sheng Que, Li Chen. Management of differentiated thyroid carcinoma with bone metastasis: a case report and review of the Chinese literature[J]. Journal of Zhejiang University Science B, 2014, 15(12): 1081-1087.
@article{title="Management of differentiated thyroid carcinoma with bone metastasis: a case report and review of the Chinese literature",
author="Wei-dong Zhang, Da-ren Liu, Cheng-cheng Feng, Chuan-biao Zhou, Chen-ni Zhan, Ri-sheng Que, Li Chen",
journal="Journal of Zhejiang University Science B",
volume="15",
number="12",
pages="1081-1087",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400124"
}
%0 Journal Article
%T Management of differentiated thyroid carcinoma with bone metastasis: a case report and review of the Chinese literature
%A Wei-dong Zhang
%A Da-ren Liu
%A Cheng-cheng Feng
%A Chuan-biao Zhou
%A Chen-ni Zhan
%A Ri-sheng Que
%A Li Chen
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 12
%P 1081-1087
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400124
TY - JOUR
T1 - Management of differentiated thyroid carcinoma with bone metastasis: a case report and review of the Chinese literature
A1 - Wei-dong Zhang
A1 - Da-ren Liu
A1 - Cheng-cheng Feng
A1 - Chuan-biao Zhou
A1 - Chen-ni Zhan
A1 - Ri-sheng Que
A1 - Li Chen
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 12
SP - 1081
EP - 1087
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400124
Abstract: Differentiated thyroid carcinoma (DTC) is a common malignancy. The general treatments are thyroidectomy of the affected lobe along with lymphadenectomy. However, bone metastasis is rare in DTC compared with other malignancies and the management of metastasis foci is still controversial. Here we present a case of follicular thyroid carcinoma with the 6th cervical vertebra body metastasis successfully treated by total thyroidectomy, cervical corpectomy, and internal fixation, followed by hormone replacement therapy and radioiodine therapy. Eleven additional patients diagnosed as thyroid carcinoma with bone metastasis collected from Chinese literature between January 1996 and December 2013 were also reviewed. The mean age of the 12 patients at presentation was (53.9±9.2) years (rang, 42–72 years) and the male to female ratio was 1:2. Nine cases received total/near-total thyroidectomy or lobectomy while the other three patients refused for personal reasons. The interventions for bone metastasis were one-stage operation (9/12), I131 adjuvant therapy (3/12), chemotherapy (1/12), and no intervention (1/12). During the follow-up, two patients died of metastatic carcinoma recurrence, one died of multiple organ metastasis, and one with an unknown reason. We conclude that the management of thyroid carcinoma with bone metastasis needs multidisciplinary cooperation. Surgical resection is still the first choice for cure, while the combined one-stage operation on the primary and metastatic sites followed by hormone replacement therapy and radioiodine therapy is an applicable treatment.
ORCID: 
Open peer comments: Debate/Discuss/Question/Opinion
<1>