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CLC number: R964

On-line Access: 2016-07-06

Received: 2015-12-18

Revision Accepted: 2016-01-21

Crosschecked: 2016-06-18

Cited: 0

Clicked: 3549

Citations:  Bibtex RefMan EndNote GB/T7714


Pan Xu


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.7 P.503-514


Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice

Author(s):  Pan Xu, Shu-ping Xu, Ke-zhu Wang, Cong Lu, Hong-xia Zhang, Rui-le Pan, Chang Qi, Yan-yan Yang, Ying-hui Li, Xin-min Liu

Affiliation(s):  Research Center of Pharmacology and Toxicology, Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China; more

Corresponding email(s):   liuxinmin@hotmail.com

Key Words:  Cognitive improvement, Hydrolysate of polygalasaponin, SAMP8 mice

Pan Xu, Shu-ping Xu, Ke-zhu Wang, Cong Lu, Hong-xia Zhang, Rui-le Pan, Chang Qi, Yan-yan Yang, Ying-hui Li, Xin-min Liu. Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice[J]. Journal of Zhejiang University Science B, 2016, 17(7): 503-514.

@article{title="Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice",
author="Pan Xu, Shu-ping Xu, Ke-zhu Wang, Cong Lu, Hong-xia Zhang, Rui-le Pan, Chang Qi, Yan-yan Yang, Ying-hui Li, Xin-min Liu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice
%A Pan Xu
%A Shu-ping Xu
%A Ke-zhu Wang
%A Cong Lu
%A Hong-xia Zhang
%A Rui-le Pan
%A Chang Qi
%A Yan-yan Yang
%A Ying-hui Li
%A Xin-min Liu
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 7
%P 503-514
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500321

T1 - Cognitive-enhancing effects of hydrolysate of polygalasaponin in SAMP8 mice
A1 - Pan Xu
A1 - Shu-ping Xu
A1 - Ke-zhu Wang
A1 - Cong Lu
A1 - Hong-xia Zhang
A1 - Rui-le Pan
A1 - Chang Qi
A1 - Yan-yan Yang
A1 - Ying-hui Li
A1 - Xin-min Liu
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 7
SP - 503
EP - 514
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500321

Objectives: The aim of the study is to evaluate the cognitive-enhancing effects of hydrolysate of polygalasaponin (HPS) on senescence accelerate mouse P8 (SAMP8) mice, an effective Alzheimer’s disease (AD) model, and to research the relevant mechanisms. Methods: The cognitive-enhancing effects of HPS on SAMP8 mice were assessed using Morris water maze (MWM) and step-through passive avoidance tests. Then N-methyl-D-aspartate (NMDA) receptor subunit expression for both the cortex and hippocampus of mice was observed using Western blotting. Results: HPS (25 and 50 mg/kg) improved the escape rate and decreased the escape latency and time spent in the target quadrant for the SAMP8 mice in the MWM after oral administration of HPS for 10 d. Moreover, it decreased error times in the passive avoidance tests. Western blotting showed that HPS was able to reverse the levels of NMDAR1 and NMDAR2B expression in the cortex or hippocampus of model mice. Conclusions: The present study suggested that HPS can improve cognitive deficits in SAMP8 mice, and this mechanism might be associated with NMDA receptor (NMDAR)-related pathways.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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