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On-line Access: 2017-01-03

Received: 2016-08-10

Revision Accepted: 2016-11-09

Crosschecked: 2016-12-16

Cited: 1

Clicked: 3111

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Bo-yu Dong

http://orcid.org/0000-0002-3415-9090

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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.1 P.76-78

http://doi.org/10.1631/jzus.B1600357


Inhibitory effect of Shenqi Fuzheng injection combined with docetaxel on lung cancer cells


Author(s):  Bo-yu Dong, Cheng Wang, Li Tan, Ning Tan, Meng-di Zhao, Yang Lu, Shou-ying Du

Affiliation(s):  New Technology and New Dosage Forms of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100102, China

Corresponding email(s):   landocean28@163.com, dushouying@263.net

Key Words:  Shenqi Fuzheng injection, Docetaxel, Lung cancer cell, Inhibition ratio


Bo-yu Dong, Cheng Wang, Li Tan, Ning Tan, Meng-di Zhao, Yang Lu, Shou-ying Du. Inhibitory effect of Shenqi Fuzheng injection combined with docetaxel on lung cancer cells[J]. Journal of Zhejiang University Science B, 2017, 18(1): 76-78.

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author="Bo-yu Dong, Cheng Wang, Li Tan, Ning Tan, Meng-di Zhao, Yang Lu, Shou-ying Du",
journal="Journal of Zhejiang University Science B",
volume="18",
number="1",
pages="76-78",
year="2017",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600357"
}

%0 Journal Article
%T Inhibitory effect of Shenqi Fuzheng injection combined with docetaxel on lung cancer cells
%A Bo-yu Dong
%A Cheng Wang
%A Li Tan
%A Ning Tan
%A Meng-di Zhao
%A Yang Lu
%A Shou-ying Du
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 1
%P 76-78
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600357

TY - JOUR
T1 - Inhibitory effect of Shenqi Fuzheng injection combined with docetaxel on lung cancer cells
A1 - Bo-yu Dong
A1 - Cheng Wang
A1 - Li Tan
A1 - Ning Tan
A1 - Meng-di Zhao
A1 - Yang Lu
A1 - Shou-ying Du
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 1
SP - 76
EP - 78
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600357


Abstract: 
This study investigated the anticancer effect of Shenqi Fuzheng (SQFZ) injection combined with docetaxel on lung cancer cell lines of A549 and Lewis lung cancer (LLC). SQFZ injection alone cannot inhibit the vitality of lung cancer cells, but the antitumor activity of SQFZ combined with docetaxel was significantly higher than that using docetaxel alone.

参芪扶正注射液与多西他赛联用对肺癌细胞抑制作用的初步研究

目的:研究参芪扶正注射液配伍多西他赛后对肺癌细胞A549和LLC生长的抑制作用。
创新点:首次发现参芪扶正注射液配伍多西他赛后能提高低浓度多西他赛对肺癌细胞的生长抑制率,且对不同肺癌细胞的抑制率有不同的增强作用。
方法:对A549及LLC细胞均设置参芪扶正注射液五个浓度单独给药、多西他赛九个浓度单独给药、参芪扶正注射液两个浓度分别联合多西他赛五个浓度给药三组。使用MTT比色法考察不同给药组对于肺癌细胞的生长抑制率,并对比多西他赛单独与联用后对细胞生长的抑制率。
结论:实验结果显示参芪扶正注射液单独使用对于两种肺癌细胞均无明显抑制作用,但是联合使用对多西他赛抗肿瘤作用有明显的增强效果。

关键词:参芪扶正注射液;多西他赛;肺癌细胞;抑制率

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Reference

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[5]Stewart, B.W., Wild, C.P., 2014. The global and regional burden of cancer. In: World Cancer Report 2014. World Health Organization, p.16-54.

[6]Zhang, W.Y., Zhang, W.M., Wang, L., et al., 2011. Sequence-dependent effect of docetaxel with gefitinib on the proliferation and signal protein expression of human lung adenocarcinoma cell SPC-A1. China J. Lung Cancer, 14(5):385-390 (in Chinese).

[7]Zhong, M.W., Li, Q.Z., Ye, H.Q., et al., 2015. Clinical observation of shenqi fuzheng injection combing docetaxel and lobaplatin in treatment of old middle-advanced stage lung cancer. Clin. J. Tradit. Chin. Med., 27(5):676-679 (in Chinese).

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