Full Text:   <1823>

Summary:  <1029>

CLC number: R783

On-line Access: 2018-07-04

Received: 2016-11-13

Revision Accepted: 2017-07-23

Crosschecked: 2018-06-06

Cited: 0

Clicked: 2776

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Christian Mehl

https://orcid.org/0000-0001-7541-1021

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.7 P.525-534

http://doi.org/10.1631/jzus.B1600505


Effect of ultraviolet photofunctionalization of dental titanium implants on osseointegration


Author(s):  Christian Mehl, Matthias Kern, Friederike Neumann, Telse Bhr, Jrg Wiltfang, Volker Gassling

Affiliation(s):  Department of Prosthodontics, Propaedeutics and Dental Materials, Christian-Albrechts University at Kiel, Arnold-Heller-Strae 16, 24105, Kiel, Germany; more

Corresponding email(s):   Christian.Mehl@HarderMehl.de

Key Words:  Dental implant, Osseointegration, Photofunctionalization


Christian Mehl, Matthias Kern, Friederike Neumann, Telse Bhr, Jrg Wiltfang, Volker Gassling. Effect of ultraviolet photofunctionalization of dental titanium implants on osseointegration[J]. Journal of Zhejiang University Science B, 2018, 19(7): 525-534.

@article{title="Effect of ultraviolet photofunctionalization of dental titanium implants on osseointegration",
author="Christian Mehl, Matthias Kern, Friederike Neumann, Telse Bhr, Jrg Wiltfang, Volker Gassling",
journal="Journal of Zhejiang University Science B",
volume="19",
number="7",
pages="525-534",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600505"
}

%0 Journal Article
%T Effect of ultraviolet photofunctionalization of dental titanium implants on osseointegration
%A Christian Mehl
%A Matthias Kern
%A Friederike Neumann
%A Telse Bhr
%A Jrg Wiltfang
%A Volker Gassling
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 7
%P 525-534
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600505

TY - JOUR
T1 - Effect of ultraviolet photofunctionalization of dental titanium implants on osseointegration
A1 - Christian Mehl
A1 - Matthias Kern
A1 - Friederike Neumann
A1 - Telse Bhr
A1 - Jrg Wiltfang
A1 - Volker Gassling
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 7
SP - 525
EP - 534
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600505


Abstract: 
Objective: The aim of the current study was to evaluate the effect of ultraviolet (UV) photofunctionalization of dental titanium implants with exposure to the oral cavity on osseointegration in an animal model. Methods: Forty-eight titanium implants (Camlog® Conelog® 4.3 mmx9.0 mm) were placed epicrestally into the edentulous jaws of three minipigs and implant stability was assessed by measuring the implant stability quotient (ISQ). Prior to implantation half of the implants were photofunctionalized with intense UV-light. After three months, the implants were exposed and ISQ was measured again. After six months of implant exposure, the minipigs were sacrificed and the harvested specimens were analyzed using histomorphometric, light, and fluorescence microscopy. Main results: Forty-two of 48 implants osseointegrated. The overall mean bone-implant contact area (BIC) was (64±22)%. No significant differences were found in BIC or ISQ value (multivariate analysis of variance (MANOVA), P>0.05) between implants with and without exposure to UV photofunctionalization. Conclusions: No significant effects were observed on osseointegration of dental titanium implants nine months after exposure of UV photofunctionalization.

牙钛种植体的紫外线光化功能对骨整合的影响

目的:通过在动物模组上植入钛种植体,测量紫外线光化功能对于骨整合的作用和影响.
方法:在三只小型猪的无牙颌中植入共48个钛种植体 (Camlog® Conelog® 4.3 mm×9.0 mm),测量其植体稳定度数值(ISQ).在植入手术前,用强紫外光对一半的种植体进行光化处理.植入手术三个月后,暴露种植体,再次测量ISQ.在暴露种植体六个月后,处死动物,通过组织形态学、光学和荧光显微镜对采样标本进行分析.
结论:在48个种植体中,42个完成骨整合.总平均骨-植入物的接触面积(BIC)为(64±22)%.作为实验因素的小型猪及紫外线光化功能没有造成BIC和ISQ值的显著差异(P>0.05,多元方差分析).九个月后,对钛种植体进行紫外线光化处理,没有对骨结合产生显著的影响.

关键词:种植牙;骨结合;光化功能

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Abboud M, Koeck B, Stark H, et al., 2005. Immediate loading of single-tooth implants in the posterior region. Int J Oral Maxillofac Implants, 20(1):61-68.

[2]Adell R, Lekholm U, Rockler B, et al., 1981. A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int J Oral Surg, 10(6):387-416.

[3]Aita H, Hori N, Takeuchi M, et al., 2009. The effect of ultraviolet functionalization of titanium on integration with bone. Biomaterials, 30(6):1015-1025.

[4]Att W, Ogawa T, 2012. Biological aging of implant surfaces and their restoration with ultraviolet light treatment: a novel understanding of osseointegration. Int J Oral Maxillofac Implants, 27(4):753-761.

[5]Becker ST, Bolte H, Krapf O, et al., 2009. Endocultivation: 3D printed customized porous scaffolds for heterotopic bone induction. Oral Oncol, 45(11):e181-e188.

[6]Bergkvist G, Nilner K, Sahlholm S, et al., 2009. Immediate loading of implants in the edentulous maxilla: use of an interim fixed prosthesis followed by a permanent fixed prosthesis: a 32-month prospective radiological and clinical study. Clin Implant Dent Relat Res, 11(1):1-10.

[7]Berglundh T, Abrahamsson I, Albouy JP, et al., 2007. Bone healing at implants with a fluoride-modified surface: an experimental study in dogs. Clin Oral Implants Res, 18(2):147-152.

[8]Chuang SK, Wei LJ, Douglass CW, et al., 2002. Risk factors for dental implant failure: a strategy for the analysis of clustered failure-time observations. J Dent Res, 81(8):572-577.

[9]Covani U, Ricci M, Bozzolo G, et al., 2011. Analysis of the pattern of the alveolar ridge remodelling following single tooth extraction. Clin Oral Implants Res, 22(8):820-825.

[10]de Maeztu MA, Braceras I, Alava JI, et al., 2008. Improvement of osseointegration of titanium dental implant surfaces modified with CO ions: a comparative histomorphometric study in beagle dogs. Int J Oral Maxillofac Surg, 37(5):441-447.

[11]Donath K, Breuner G, 1982. A method for the study of undecalcified bones and teeth with attached soft tissues. The Säge-Schliff (sawing and grinding) technique. J Oral Pathol, 11(4):318-326.

[12]Elsubeihi ES, Heersche JN, 2004. Quantitative assessment of post-extraction healing and alveolar ridge remodelling of the mandible in female rats. Arch Oral Biol, 49(5):401-412.

[13]Eriksen EF, Gundersen HJ, Melsen F, et al., 1984. Reconstruction of the formative site in iliac trabecular bone in 20 normal individuals employing a kinetic model for matrix and mineral apposition. Metab Bone Dis Relat Res, 5(5):243-252.

[14]Funato A, Ogawa T, 2013. Photofunctionalized dental implants: a case series in compromised bone. Int J Oral Maxillofac Implants, 28(6):1589-1601.

[15]https://doi.org/10.11607/jomi.3232

[16]Funato A, Yamada M, Ogawa T, 2013. Success rate, healing time, and implant stability of photofunctionalized dental implants. Int J Oral Maxillofac Implants, 28(5):1261-1271.

[17]https://doi.org/10.11607/jomi.3263

[18]Heydecke G, McFarland DH, Feine JS, et al., 2004. Speech with maxillary implant prostheses: ratings of articulation. J Dent Res, 83(3):236-240.

[19]Ishii K, Matsuo M, Hoshi N, et al., 2016. Effect of ultraviolet irradiation of the implant surface on progression of periimplantitis—a pilot study in dogs. Implant Dent, 25(1):47-53.

[20]Lentrodt J, Bull HG, 1976. Animal experimental studies on bone regeneration following drilling of the bone. Dtsch Zahnarztl Z, 31(2):115-124 (in German).

[21]Maló P, de Araújo Nobre M, Lopes A, et al., 2012. ‘All-on-4’ immediate-function concept for completely edentulous maxillae: a clinical report on the medium (3 years) and long-term (5 years) outcomes. Clin Implant Dent Relat Res, 14(Suppl 1):e139-e150.

[22]Mehl C, Becker ST, Acil Y, et al., 2013. Impact of vertical loading on the implant-bone interface. Clin Oral Implants Res, 24(8):949-956.

[23]Melas F, Marcenes W, Wright PS, 2001. Oral health impact on daily performance in patients with implant-stabilized overdentures and patients with conventional complete dentures. Int J Oral Maxillofac Implants, 16(5):700-712.

[24]Mosekilde L, 1995. Assessing bone quality—animal models in preclinical osteoporosis research. Bone, 17(4 Suppl):S343-S352.

[25]Mosekilde L, Kragstrup J, Richards A, 1987. Compressive strength, ash weight, and volume of vertebral trabecular bone in experimental fluorosis in pigs. Calcif Tissue Int, 40(6):318-322.

[26]Moy PK, Medina D, Shetty V, et al., 2005. Dental implant failure rates and associated risk factors. Int J Oral Maxillofac Implants, 20(4):569-577.

[27]Nibali L, 2015. Aggressive periodontitis: microbes and host response, who to blame? Virulence, 6(3):223-228.

[28]Nishimura K, Kato T, Ito T, et al., 2014. Influence of titanium ions on cytokine levels of murine splenocytes stimulated with periodontopathic bacterial lipopolysaccharide. Int J Oral Maxillofac Implants, 29(2):472-477.

[29]https://doi.org/10.11607/jomi.3434

[30]Ogawa T, 2014. Ultraviolet photofunctionalization of titanium implants. Int J Oral Maxillofac Implants, 29(1):e95-e102.

[31]https://doi.org/10.11607/jomi.te47

[32]Ogawa T, Nishimura I, 2003. Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes. Int J Oral Maxillofac Implants, 18(2):200-210.

[33]Park DS, Kim IS, Kim H, et al., 2010. Improved biocompatibility of hydroxyapatite thin film prepared by aerosol deposition. J Biomed Mater Res B Appl Biomater, 94(2):353-358.

[34]Park KH, Koak JY, Kim SK, et al., 2013. The effect of ultraviolet-C irradiation via a bactericidal ultraviolet sterilizer on an anodized titanium implant: a study in rabbits. Int J Oral Maxillofac Implants, 28(1):57-66.

[35]https://doi.org/10.11607/jomi.2638

[36]Pyo SW, Park YB, Moon HS, et al., 2013. Photofunctionalization enhances bone-implant contact, dynamics of interfacial osteogenesis, marginal bone seal, and removal torque value of implants: a dog jawbone study. Implant Dent, 22(6):666-675.

[37]Suzuki S, Kobayashi H, Ogawa T, 2013. Implant stability change and osseointegration speed of immediately loaded photofunctionalized implants. Implant Dent, 22(5):481-490.

[38]Tealdo T, Bevilacqua M, Pera F, et al., 2008. Immediate function with fixed implant-supported maxillary dentures: a 12-month pilot study. J Prosthet Dent, 99(5):351-360.

[39]Urban IA, Jovanovic SA, Lozada JL, 2009. Vertical ridge augmentation using guided bone regeneration (GBR) in three clinical scenarios prior to implant placement: a retrospective study of 35 patients 12 to 72 months after loading. Int J Oral Maxillofac Implants, 24(3):502-510.

[40]van Kampen FM, van der Bilt A, Cune MS, et al., 2004. Masticatory function with implant-supported overdentures. J Dent Res, 83(9):708-711.

[41]Wang R, Hashimoto K, Fujishima A, 1997. Light-induced amphiphilic surfaces. Nature, 388:431-432.

[42]Weinlaender M, Kenney EB, Lekovic V, et al., 1992. Histomorphometry of bone apposition around three types of endosseous dental implants. Int J Oral Maxillofac Implants, 7(4):491-496.

[43]Zarb GA, Schmitt A, 1990. Terminal dentition in elderly patients and implant therapy alternatives. Int Dent J, 40(2):67-73.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2022 Journal of Zhejiang University-SCIENCE