Full Text:   <1939>

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CLC number: B845

On-line Access: 2018-08-02

Received: 2017-09-21

Revision Accepted: 2017-12-04

Crosschecked: 2018-07-06

Cited: 0

Clicked: 3351

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Shao-wei Xue

https://orcid.org/0000-0001-5441-4522

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.8 P.643-653

http://doi.org/10.1631/jzus.B1700481


Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults


Author(s):  Shao-wei Xue, Tien-wen Lee, Yong-hu Guo

Affiliation(s):  Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou 311121, China; more

Corresponding email(s):   xuedrm@126.com

Key Words:  Trait anxiety, Fractional amplitude of low-frequency fluctuation (fALFF), Medial orbitofrontal cortex, Precuneus, Functional connectivity


Shao-wei Xue, Tien-wen Lee, Yong-hu Guo. Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults[J]. Journal of Zhejiang University Science B, 2018, 19(8): 643-653.

@article{title="Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults",
author="Shao-wei Xue, Tien-wen Lee, Yong-hu Guo",
journal="Journal of Zhejiang University Science B",
volume="19",
number="8",
pages="643-653",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700481"
}

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%T Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults
%A Shao-wei Xue
%A Tien-wen Lee
%A Yong-hu Guo
%J Journal of Zhejiang University SCIENCE B
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%P 643-653
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%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700481

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T1 - Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults
A1 - Shao-wei Xue
A1 - Tien-wen Lee
A1 - Yong-hu Guo
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 8
SP - 643
EP - 653
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1700481


Abstract: 
medial orbitofrontal cortex (mOFC) abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined. Here, we conducted a resting state functional magnetic resonance imaging (R-fMRI) study with 56 healthy male adults from the Nathan Kline Institute/Rockland Sample (NKI-RS) to examine the relationship between the fractional amplitude of low-frequency fluctuation (fALFF) signals and trait anxiety across the whole brain. A Louvain method for module detection based on graph theory was further employed in the automated functional subdivision to explore subregional correlates of trait anxiety. The results showed that trait anxiety was related to fALFF in the mOFC. Additionally, the resting-state functional connectivity (RSFC) between the right subregions of the mOFC and the precuneus was correlated with trait anxiety. These findings provided evidence about the involvement of the mOFC in anxiety processing among the healthy population.

成年男性特质型焦虑与内侧眶额的自发活动有关

目的:研究内侧眶额与焦虑加工的关系.
创新点:采用Louvain网络模块检测方法对大脑内侧眶额进行自动化功能亚区分割,并发现内侧眶额与健康成年男性特质型焦虑的关系.
方法:采用静息态低频振幅比率(fALFF)、静息态功能连通性(RSFC)和脑区功能亚区自动化分割方法.
结论:成年男性特质型焦虑分数与内侧眶额的fALFF指标间存在显著相关性,并与右脑内侧眶额和楔前叶之间的功能连通性有关.因此,可以认为内侧眶额涉及特质型焦虑加工.

关键词:特质型焦虑;低频振幅比率;内侧眶额;楔前叶;功能连通性

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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