Full Text:   <1939>

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CLC number: B845

On-line Access: 2018-08-02

Received: 2017-09-21

Revision Accepted: 2017-12-04

Crosschecked: 2018-07-06

Cited: 0

Clicked: 3351

Citations:  Bibtex RefMan EndNote GB/T7714


Shao-wei Xue


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.8 P.643-653


Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults

Author(s):  Shao-wei Xue, Tien-wen Lee, Yong-hu Guo

Affiliation(s):  Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou 311121, China; more

Corresponding email(s):   xuedrm@126.com

Key Words:  Trait anxiety, Fractional amplitude of low-frequency fluctuation (fALFF), Medial orbitofrontal cortex, Precuneus, Functional connectivity

Shao-wei Xue, Tien-wen Lee, Yong-hu Guo. Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults[J]. Journal of Zhejiang University Science B, 2018, 19(8): 643-653.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults
%A Shao-wei Xue
%A Tien-wen Lee
%A Yong-hu Guo
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700481

T1 - Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults
A1 - Shao-wei Xue
A1 - Tien-wen Lee
A1 - Yong-hu Guo
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 8
SP - 643
EP - 653
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700481

medial orbitofrontal cortex (mOFC) abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined. Here, we conducted a resting state functional magnetic resonance imaging (R-fMRI) study with 56 healthy male adults from the Nathan Kline Institute/Rockland Sample (NKI-RS) to examine the relationship between the fractional amplitude of low-frequency fluctuation (fALFF) signals and trait anxiety across the whole brain. A Louvain method for module detection based on graph theory was further employed in the automated functional subdivision to explore subregional correlates of trait anxiety. The results showed that trait anxiety was related to fALFF in the mOFC. Additionally, the resting-state functional connectivity (RSFC) between the right subregions of the mOFC and the precuneus was correlated with trait anxiety. These findings provided evidence about the involvement of the mOFC in anxiety processing among the healthy population.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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