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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.7 P.541-549


Recent advances in the neural regulation of feeding behavior in adult Drosophila

Author(s):  Gao-Hang Wang, Li-Ming Wang

Affiliation(s):  MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China

Corresponding email(s):   lmwang83@zju.edu.cn

Key Words:  Feeding behavior, Drosophila melanogaster, Neuromodulatory regulation, Internal status, Sensory processing

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Gao-Hang Wang, Li-Ming Wang. Recent advances in the neural regulation of feeding behavior in adult Drosophila[J]. Journal of Zhejiang University Science B, 2019, 20(7): 541-549.

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T1 - Recent advances in the neural regulation of feeding behavior in adult Drosophila
A1 - Gao-Hang Wang
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900080

The ability to maintain metabolic homeostasis is a key capability critical for the survival and well-being of animals living in constantly changing environments. Metabolic homeostasis depends on neuromodulators, such as biogenic amines, neuropeptides, and hormones, to signal changes in animals’ internal metabolic status and to orchestrate their behaviors accordingly. An important example is the regulation of feeding behavior by conserved molecular and cellular mechanisms across the animal kingdom. Its relatively simple brain coupled with well-characterized genetics and behavioral paradigms makes the fruit fly Drosophila melanogaster an excellent model for investigating the neuromodulatory regulation of feeding behavior. In this review we discuss the neuromodulators and neural circuits that integrate the internal physiological status with external sensory cues and modulate feeding behavior in adult fruit flies. Studies show that various specific aspects of feeding behavior are subjected to unique neuromodulatory regulation, which permits fruit flies to maintain metabolic homeostasis effectively.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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