Full Text:   <1252>

Summary:  <1108>

CLC number: R777.1

On-line Access: 2019-07-05

Received: 2019-02-22

Revision Accepted: 2019-04-01

Crosschecked: 2019-06-13

Cited: 0

Clicked: 2118

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yu-feng Yao

https://orcid.org/0000-0003-1494-9711

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.8 P.679-686

http://doi.org/10.1631/jzus.B1900091


Eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye: a preliminary investigation


Author(s):  Wen-jia Xie, Lou-jing Jiang, Xia Zhang, Ye-sheng Xu, Yu-feng Yao

Affiliation(s):  Department of Ophthalmology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China

Corresponding email(s):   yaoyf@zju.edu.cn

Key Words:  Eyelid margin cleaning, Deep Cleaning Device, Meibomian gland dysfunction, Dry eye


Wen-jia Xie, Lou-jing Jiang, Xia Zhang, Ye-sheng Xu, Yu-feng Yao. Eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye: a preliminary investigation[J]. Journal of Zhejiang University Science B, 2019, 20(8): 679-686.

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author="Wen-jia Xie, Lou-jing Jiang, Xia Zhang, Ye-sheng Xu, Yu-feng Yao",
journal="Journal of Zhejiang University Science B",
volume="20",
number="8",
pages="679-686",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900091"
}

%0 Journal Article
%T Eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye: a preliminary investigation
%A Wen-jia Xie
%A Lou-jing Jiang
%A Xia Zhang
%A Ye-sheng Xu
%A Yu-feng Yao
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 8
%P 679-686
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900091

TY - JOUR
T1 - Eyelid margin cleaning using Deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye: a preliminary investigation
A1 - Wen-jia Xie
A1 - Lou-jing Jiang
A1 - Xia Zhang
A1 - Ye-sheng Xu
A1 - Yu-feng Yao
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 8
SP - 679
EP - 686
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900091


Abstract: 
Objective: To evaluate the safety and effectiveness of eyelid margin cleaning using deep Cleaning Device for the treatment of meibomian gland dysfunction-associated dry eye. Methods: This was a prospective, randomized, open-label, investigator-masked, and self-controlled study. We randomly assigned one eye of patients with meibomian gland dysfunction-associated dry eye to the treatment group, and the other eye to the control group. Both groups received artificial tears and lid warming; the treatment group received an additional one-time in-office eyelid margin cleaning using deep Cleaning Device. Non-invasive tear break-up time (NITBUT) and tear meniscus height (TMH) of each eye, and Standard Patient Evaluation for Eye Dryness II (SPEED II) score of each patient were evaluated before and at one week after treatment. Results: Thirty eyes of 15 patients were enrolled. No adverse effects occurred during the treatment. Compared with the baseline values, the SPEED score decreased significantly at one week after treatment (mean±95% confidence interval, 11.00±0.99 vs. 5.67±1.67, P<0.0001), the NITBUT-first in the treatment group increased significantly at one week after treatment ((4.74±1.27) s vs. (7.49±2.22) s, P=0.01). The NITBUT-first was significantly longer in the treatment group ((7.49±2.22) s) than in the control group ((5.17±0.91) s) at one week after treatment (P=0.042). No significant differences were found in other tear film parameters between the two groups. Conclusions: eyelid margin cleaning using the novel deep Cleaning Device is a convenient, effective, and safe treatment for patients with meibomian gland dysfunction-associated dry eye.

深度清洁装置清洁睑缘治疗睑板腺功能障碍相关干眼症的初步研究

目的:评价深度清洁装置清洁睑缘治疗睑板腺功能障碍相关干眼症的安全性和有效性.
创新点:评估了一个干眼症治疗新方法的疗效.
方法:将睑板腺功能障碍相关干眼症患者的两只眼随机分入治疗组和对照组.对照组进行人工泪液和眼睑热敷治疗,治疗组在上述治疗基础上加用深度清洁装置进行一次睑缘清洁.在基线和治疗一周后测量非侵入性泪膜破裂时间和泪河高度,用问卷调查表对每个人干眼症状进行评分.
结论:深度清洁装置睑缘清洁是一种安全有效的方法,适用于睑板腺功能障碍相关干眼症患者.

关键词:睑缘清洁;深度清洁装置;睑板腺功能障碍;干眼症

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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