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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.5 P.414-427


Bile-ology: from bench to bedside

Author(s):  Li-Hua Jin, Zhi-Peng Fang, Min-Jie Fan, Wen-Dong Huang

Affiliation(s):  Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA; more

Corresponding email(s):   whuang@coh.org

Key Words:  Bile acid, Gut microbiota, Farnesoid X receptor, G protein-coupled bile acid receptor, Metabolic disease

Li-Hua Jin, Zhi-Peng Fang, Min-Jie Fan, Wen-Dong Huang. Bile-ology: from bench to bedside[J]. Journal of Zhejiang University Science B, 2019, 20(5): 414-427.

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author="Li-Hua Jin, Zhi-Peng Fang, Min-Jie Fan, Wen-Dong Huang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Bile-ology: from bench to bedside
%A Li-Hua Jin
%A Zhi-Peng Fang
%A Min-Jie Fan
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%J Journal of Zhejiang University SCIENCE B
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%N 5
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%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900158

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A1 - Li-Hua Jin
A1 - Zhi-Peng Fang
A1 - Min-Jie Fan
A1 - Wen-Dong Huang
J0 - Journal of Zhejiang University Science B
VL - 20
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%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900158

bile acids (BAs) are originally known as detergents essential for the digestion and absorption of lipids. In recent years, extensive research has unveiled new functions of BAs as gut hormones that modulate physiological and pathological processes, including glucose and lipid metabolism, energy expenditure, inflammation, tumorigenesis, cardiovascular disease, and even the central nervous system in addition to cholesterol homeostasis, enterohepatic protection and liver regeneration. BAs are closely linked with gut microbiota which might explain some of their crucial roles in organs. The signaling actions of BAs can also be mediated through specific nuclear receptors and membrane-bound G protein-coupled receptors. Several pharmacological agents or bariatric surgeries have demonstrated efficacious therapeutic effects on metabolic diseases through targeting BA signaling. In this mini-review, we summarize recent advances in bile-ology, focusing on its translational studies.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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