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On-line Access: 2019-10-09

Received: 2019-04-21

Revision Accepted: 2019-07-09

Crosschecked: 2019-09-12

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.11 P.868-876


Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein

Author(s):  Zhi-Hao Tao, Chang Li, Xiao-Fei Xu, Yuan-Jiang Pan

Affiliation(s):  Department of Chemistry, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   lichang@zju.edu.cn, panyuanjiang@zju.edu.cn

Key Words:  Acrolein, Reactive carbonyl species, Ferulic acid, Cytotoxicity, Oxidative stress

Zhi-Hao Tao, Chang Li, Xiao-Fei Xu, Yuan-Jiang Pan. Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein[J]. Journal of Zhejiang University Science B, 2019, 20(11): 868-876.

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author="Zhi-Hao Tao, Chang Li, Xiao-Fei Xu, Yuan-Jiang Pan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein
%A Zhi-Hao Tao
%A Chang Li
%A Xiao-Fei Xu
%A Yuan-Jiang Pan
%J Journal of Zhejiang University SCIENCE B
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%N 11
%P 868-876
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900211

T1 - Scavenging activity and mechanism study of ferulic acid against reactive carbonyl species acrolein
A1 - Zhi-Hao Tao
A1 - Chang Li
A1 - Xiao-Fei Xu
A1 - Yuan-Jiang Pan
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 11
SP - 868
EP - 876
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900211

acrolein, known as one of the most common reactive carbonyl species, is a toxic small molecule affecting human health in daily life. This study is focused on the scavenging abilities and mechanism of ferulic acid and some other phenolic acids against acrolein. Among the 13 phenolic compounds investigated, ferulic acid was found to have the highest efficiency in scavenging acrolein under physiological conditions. ferulic acid remained at (3.04±1.89)% and acrolein remained at (29.51±4.44)% after being incubated with each other for 24 h. The molecular mechanism of the detoxifying process was also studied. Detoxifying products, namely 2-methoxy-4-vinylphenol (product 21) and 5-(4-hydroxy-3-methoxyphenyl)pent-4-enal (product 22), were identified though nuclear magnetic resonance (NMR) and gas chromatography-mass spectrometry (GC-MS), after the scavenging process. ferulic acid showed significant activity in scavenging acrolein under physiological conditions. This study indicates a new method for inhibiting damage from acrolein.




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[42]List of electronic supplementary materials

[43]Fig. S1 GC-MS of product 21

[44]Fig. S2 1H-NMR results of product 21

[45]Fig. S3 NMR results of product 22

[46]Fig. S4 Structures of compounds 2325

[47]Table S1 Diseases proved to be related to acrolein

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