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Suppl. Mater.: 

CLC number: R735.7

On-line Access: 2019-10-09

Received: 2019-07-03

Revision Accepted: 2019-09-12

Crosschecked: 2019-09-12

Cited: 0

Clicked: 2970

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Hai-tao Yu

https://orcid.org/0000-0003-2342-5397

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.11 P.928-932

http://doi.org/10.1631/jzus.B1900343


Integrated analysis of hypoxia-induced miR-210 signature as a potential prognostic biomarker of hepatocellular carcinoma: a study based on The Cancer Genome Atlas


Author(s):  Yi Dai, Ji-liang Shen, Xue-yong Zheng, Tian-yu Lin, Hai-tao Yu

Affiliation(s):  Zhejiang Provincial Key Laboratory of Laparoscopic Technology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   3411053@zju.edu.cn

Key Words:  miR-210, The Cancer Genome Atlas (TCGA), Hepatocellular carcinoma (HCC), Hypoxia, prognostic biomarker


Yi Dai, Ji-liang Shen, Xue-yong Zheng, Tian-yu Lin, Hai-tao Yu. Integrated analysis of hypoxia-induced miR-210 signature as a potential prognostic biomarker of hepatocellular carcinoma: a study based on The Cancer Genome Atlas[J]. Journal of Zhejiang University Science B, 2019, 20(11): 928-932.

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author="Yi Dai, Ji-liang Shen, Xue-yong Zheng, Tian-yu Lin, Hai-tao Yu",
journal="Journal of Zhejiang University Science B",
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doi="10.1631/jzus.B1900343"
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%A Yi Dai
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T1 - Integrated analysis of hypoxia-induced miR-210 signature as a potential prognostic biomarker of hepatocellular carcinoma: a study based on The Cancer Genome Atlas
A1 - Yi Dai
A1 - Ji-liang Shen
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A1 - Tian-yu Lin
A1 - Hai-tao Yu
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Abstract: 
hepatocellular carcinoma (HCC) is one of the most common types of liver cancer and is the second leading cause of cancer mortality with an estimated 745 500 deaths annually (Jemal et al., 2011). Although new therapeutic modalities including novel chemotherapeutic interventions and targeted therapy have been applied, the prognosis of HCC patients remains unsatisfactory due to the high incidence of intrahepatic and distal metastases (Siegel et al., 2018).

一项基于肿瘤基因数据库关于综合分析缺氧导致的肝细胞癌的蛋白预测标志物miR-210变化的研究

目的:研究肝癌细胞缺氧微环境导致miR-210表达变化与肿瘤进展、预后等相关性.
创新点:首次阐明了miR-210表达与肝癌预后及缺氧相关基因的关系.
方法:选取肿瘤基因数据库(TCGA)中424位肝癌患者的miR-210表达水平、临床病理参数及缺氧相关基因(HIF1αHIF3αPTPN1BNIP3)表达量,研究miR-210与肝癌预后及缺氧基因之间的相关性.
结论:miR-210的表达与肝细胞癌进展分期呈正相关,它的高表达预示更低的无瘤生存率.因此,推测miR-210可能与肿瘤细胞缺氧相关性死亡有关.

关键词:miR-210;肿瘤基因数据库(TCGA);肝细胞癌(HCC);缺氧;预后意义

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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[20]List of electronic supplementary materials

[21]Table S1 Clinicopathological parameters of the patients

[22]Table S2 Univariate and multivariate analyses of survival in 424 patients with HCC according to clinicopathologic factors and miR-210 expression

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