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On-line Access: 2021-09-10

Received: 2020-11-16

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Yuehong ZHENG


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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.9 P.733-745


Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics

Author(s):  Lei JI, Siliang CHEN, Guangchao GU, Wei WANG, Jinrui REN, Fang XU, Fangda LI, Jianqiang WU, Dan YANG, Yuehong ZHENG

Affiliation(s):  Department of Vascular Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China; more

Corresponding email(s):   yuehongzheng@yahoo.com

Key Words:  Abdominal aortic aneurysm (AAA), Atherosclerosis (AS), Untargeted metabolomics, Transcriptomics

Lei JI, Siliang CHEN, Guangchao GU, Wei WANG, Jinrui REN, Fang XU, Fangda LI, Jianqiang WU, Dan YANG, Yuehong ZHENG. Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics[J]. Journal of Zhejiang University Science B, 2021, 22(9): 733-745.

@article{title="Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics",
author="Lei JI, Siliang CHEN, Guangchao GU, Wei WANG, Jinrui REN, Fang XU, Fangda LI, Jianqiang WU, Dan YANG, Yuehong ZHENG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics
%A Lei JI
%A Siliang CHEN
%A Guangchao GU
%A Jinrui REN
%A Fang XU
%A Fangda LI
%A Jianqiang WU
%A Yuehong ZHENG
%J Journal of Zhejiang University SCIENCE B
%V 22
%N 9
%P 733-745
%@ 1673-1581
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000713

T1 - Discovery of potential biomarkers for human atherosclerotic abdominal aortic aneurysm through untargeted metabolomics and transcriptomics
A1 - Lei JI
A1 - Siliang CHEN
A1 - Guangchao GU
A1 - Wei WANG
A1 - Jinrui REN
A1 - Fang XU
A1 - Fangda LI
A1 - Jianqiang WU
A1 - Dan YANG
A1 - Yuehong ZHENG
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 9
SP - 733
EP - 745
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000713

abdominal aortic aneurysm (AAA) and atherosclerosis (AS) have considerable similarities in clinical risk factors and molecular pathogenesis. The aim of our study was to investigate the differences between AAA and AS from the perspective of metabolomics, and to explore the potential mechanisms of differential metabolites via integration analysis with transcriptomics. Plasma samples from 32 AAA and 32 AS patients were applied to characterize the metabolite profiles using untargeted liquid chromatography-mass spectrometry (LC-MS). A total of 18 remarkably different metabolites were identified, and a combination of seven metabolites could potentially serve as a biomarker to distinguish AAA and AS, with an area under the curve (AUC) of 0.93. Subsequently, we analyzed both the metabolomics and transcriptomics data and found that seven metabolites, especially 2'-deoxy-D-ribose (2dDR), were significantly correlated with differentially expressed genes. In conclusion, our study presents a comprehensive landscape of plasma metabolites in AAA and AS patients, and provides a research direction for pathogenetic mechanisms in atherosclerotic AAA.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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