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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2100789


MiR-22 targets ELOVL6 to regulate fatty acid composition and mitochondrial morphology in skeletal muscle cells


Author(s):  Han WANG, Moran HU, Zhonghao SHEN, Zhaoxue DING, Xiaolong ZHOU, Songbai YANG, Ke HE, Xiangchen LI, Ayong ZHAO

Affiliation(s):  Key Laboratory of Applied Technology on Green-Eco Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology, College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, China

Corresponding email(s):   zay503@zafu.edu.cn

Key Words:  miR-22, ELOVL family member 6, fatty acid composition, mitochondrial morphology


Han WANG, Moran HU, Zhonghao SHEN, Zhaoxue DING, Xiaolong ZHOU, Songbai YANG, Ke HE, Xiangchen LI, Ayong ZHAO. MiR-22 targets ELOVL6 to regulate fatty acid composition and mitochondrial morphology in skeletal muscle cells[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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author="Han WANG, Moran HU, Zhonghao SHEN, Zhaoxue DING, Xiaolong ZHOU, Songbai YANG, Ke HE, Xiangchen LI, Ayong ZHAO",
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publisher="Zhejiang University Press & Springer",
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%T MiR-22 targets ELOVL6 to regulate fatty acid composition and mitochondrial morphology in skeletal muscle cells
%A Han WANG
%A Moran HU
%A Zhonghao SHEN
%A Zhaoxue DING
%A Xiaolong ZHOU
%A Songbai YANG
%A Ke HE
%A Xiangchen LI
%A Ayong ZHAO
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
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A1 - Han WANG
A1 - Moran HU
A1 - Zhonghao SHEN
A1 - Zhaoxue DING
A1 - Xiaolong ZHOU
A1 - Songbai YANG
A1 - Ke HE
A1 - Xiangchen LI
A1 - Ayong ZHAO
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Y1 - 1998
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2100789


Abstract: 
As important post-transcriptional regulators, microRNAs (miRNAs) are involved in the indirect regulation of meat quality. In particular, miR-22 has been suggested to be one of such miRNAs. Studies have shown that muscle fatty acid composition and mitochondrial function are closely related to meat quality. Herein, we demonstrated that the elevated expression of miR-22 significantly represses fatty acid elongation and mitochondrial morphology in C2C12 myoblasts, while the knockdown of miR-22 yields the opposite results. Furthermore, we verified that miR-22 targets the elongase of very long chain fatty acids 6 (ELOVL6) and represses its expression in muscle cells. The knockdown of ELOVL6 mimics the effect of miR-22 on fatty acid composition and mitochondrial function, while ELOVL6 overexpression restores the effects of miR-22. Overall, our findings revealed that miR-22 downregulates the elongation of fatty acids and mitochondrial morphology by inhibiting ELOVL6 expression in muscle cells.

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