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On-line Access: 2022-05-13

Received: 2021-09-15

Revision Accepted: 2022-01-27

Crosschecked: 2022-05-13

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Zhaoyang ZHANG




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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.5 P.423-431


HucMSC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway

Author(s):  Yuting XU, Li ZHANG, Dickson Kofi Wiredu OCANSEY, Bo WANG, Yilin HOU, Rong MEI, Yongmin YAN, Xu ZHANG, Zhaoyang ZHANG, Fei MAO

Affiliation(s):  Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang 212013, China; more

Corresponding email(s):   Zhangcy19791216@163.com, maofei2003@ujs.edu.cn

Key Words:  Inflammatory bowel disease, Mesenchymal stem cell-derived exosome, Long non-coding RNAs, Homeobox B13, miR3202

Yuting XU, Li ZHANG, Dickson Kofi Wiredu OCANSEY, Bo WANG, Yilin HOU, Rong MEI, Yongmin YAN, Xu ZHANG, Zhaoyang ZHANG, Fei MAO. HucMSC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway[J]. Journal of Zhejiang University Science B, 2022, 23(5): 423-431.

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A1 - Yilin HOU
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A1 - Yongmin YAN
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As a group of nonspecific inflammatory diseases affecting the intestine, inflammatory bowel disease (IBD) exhibits the characteristics of chronic recurring inflammation, and was proven to be increasing in incidence (Kaplan, 2015). IBD induced by genetic background, environmental changes, immune functions, microbial composition, and toxin exposures (Sasson et al., 2021) primarily includes ulcerative colitis (UC) and Crohn's disease (CD) with complicated clinical symptoms featured by abdominal pain, diarrhea, and even blood in stools (Fan et al., 2021; Huang et al., 2021). UC is mainly limited to the rectum and the colon, while CD usually impacts the terminal ileum and colon in a discontinuous manner (Ordás et al., 2012; Panés and Rimola, 2017). In recent years, many studies have suggested the lack of effective measures in the diagnosis and treatment of IBD, prompting an urgent need for new strategies to understand the mechanisms of and offer promising therapies for IBD.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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