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On-line Access: 2022-05-13

Received: 2021-09-15

Revision Accepted: 2022-01-27

Crosschecked: 2022-05-13

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Zhaoyang ZHANG




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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.5 P.423-431


HucMSC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway

Author(s):  Yuting XU, Li ZHANG, Dickson Kofi Wiredu OCANSEY, Bo WANG, Yilin HOU, Rong MEI, Yongmin YAN, Xu ZHANG, Zhaoyang ZHANG, Fei MAO

Affiliation(s):  Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang 212013, China; more

Corresponding email(s):   Zhangcy19791216@163.com, maofei2003@ujs.edu.cn

Key Words:  Inflammatory bowel disease, Mesenchymal stem cell-derived exosome, Long non-coding RNAs, Homeobox B13, miR3202

Yuting XU, Li ZHANG, Dickson Kofi Wiredu OCANSEY, Bo WANG, Yilin HOU, Rong MEI, Yongmin YAN, Xu ZHANG, Zhaoyang ZHANG, Fei MAO. HucMSC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway[J]. Journal of Zhejiang University Science B, 2022, 23(5): 423-431.

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A1 - Yilin HOU
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As a group of nonspecific inflammatory diseases affecting the intestine, inflammatory bowel disease (IBD) exhibits the characteristics of chronic recurring inflammation, and was proven to be increasing in incidence (Kaplan, 2015). IBD induced by genetic background, environmental changes, immune functions, microbial composition, and toxin exposures (Sasson et al., 2021) primarily includes ulcerative colitis (UC) and Crohn's disease (CD) with complicated clinical symptoms featured by abdominal pain, diarrhea, and even blood in stools (Fan et al., 2021; Huang et al., 2021). UC is mainly limited to the rectum and the colon, while CD usually impacts the terminal ileum and colon in a discontinuous manner (Ordás et al., 2012; Panés and Rimola, 2017). In recent years, many studies have suggested the lack of effective measures in the diagnosis and treatment of IBD, prompting an urgent need for new strategies to understand the mechanisms of and offer promising therapies for IBD.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]BarnhoornM, de Jonge-MullerE, MolendijkI, et al., 2018. Endoscopic administration of mesenchymal stromal cells reduces inflammation in experimental colitis. Inflamm Bowel Dis, 24(8):1755-1767.

[2]EstellerM, 2011. Non-coding RNAs in human disease. Nat Rev Genet, 12(12):861-874.

[3]FanXX, XiaQM, ZhangYY, et al., 2021. Aggregation-induced emission (AIE) nanoparticles-assisted NIR-II fluorescence imaging-guided diagnosis and surgery for inflammatory bowel disease (IBD). Adv Healthc Mater, 10(24):2101043.

[4]GanL, LvL, LiaoST, 2019. Long non-coding RNA H19 regulates cell growth and metastasis via the miR-22-3p/Snail1 axis in gastric cancer. Int J Oncol, 54(6):2157-2168.

[5]HuangLJ, MaoXT, LiYY, et al., 2021. Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease. Immunity, 54(8):‍‍1728-1744.E7.

[6]HuangZW, LeiW, HuHB, et al., 2018. H19 promotes non-small-cell lung cancer (NSCLC) development through STAT3 signaling via sponging miR-17. J Cell Physiol, 233(10):6768-6776.

[7]JatharS, KumarV, SrivastavaJ, et al., 2017. Technological Developments in lncRNA Biology. In: Rao MRS (Ed.), Long Non Coding RNA Biology. Springer, Singapore, p.283-323.

[8]JiaHY, LiuWZ, ZhangB, et al., 2018. HucMSC exosomes-delivered 14-3-3ζ enhanced autophagy via modulation of ATG16L in preventing cisplatin-induced acute kidney injury. Am J Transl Res, 10(1):101-113.

[9]JiangJJ, PiaoXY, HuSY, et al., 2020. LncRNA H19 diminishes dopaminergic neuron loss by mediating microRNA-301b-3p in Parkinson’s disease via the HPRT1-mediated Wnt/β-catenin signaling pathway. Aging (Albany NY), 12(10):8820-8836.

[10]KaplanGG, 2015. The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol, 12(12):720-727.

[11]LiuLS, LuoFY, LeiKB, 2021. Exosomes containing LINC00636 inhibit MAPK1 through the miR-450a-2-3p overexpression in human pericardial fluid and improve cardiac fibrosis in patients with atrial fibrillation. Mediators Inflamm, 2021:9960241.

[12]LiuR, TangAL, WangXY, et al., 2018. Inhibition of lncRNA NEAT1 suppresses the inflammatory response in IBD by modulating the intestinal epithelial barrier and by exosome-mediated polarization of macrophages. Int J Mol Med, 42(5):2903-2913.

[13]LucafòM, PugnettiL, BramuzzoM, et al., 2019. Long non-coding RNA GAS5 and intestinal MMP2 and MMP9 expression: a translational study in pediatric patients with IBD. Int J Mol Sci, 20(21):5280.

[14]OrdásI, EckmannL, TalaminiM, et al., 2012. Ulcerative colitis. Lancet, 380(9853):1606-1619.

[15]PaduaD, Mahurkar-JoshiS, LawIKM, et al., 2016. A long noncoding RNA signature for ulcerative colitis identifies IFNG-AS1 as an enhancer of inflammation. Am J Physiol Gastrointest Liver Physiol, 311(3):G446-G457.

[16]PanésJ, RimolaJ, 2017. Perianal fistulizing Crohn’s disease: pathogenesis, diagnosis and therapy. Nat Rev Gastroenterol Hepatol, 14(11):652-664.

[17]QianXY, ZhaoJY, YeungPY, et al., 2019. Revealing lncRNA structures and interactions by sequencing-based approaches. Trends Biochem Sci, 44(1):33-52.

[18]QiaoYQ, HuangML, XuAT, et al., 2013. LncRNA DQ786243 affects Treg related CREB and Foxp3 expression in Crohn’s disease. J Biomed Sci, 20:87.

[19]SassonAN, IngramRJM, ZhangZX, et al., 2021. The role of precision nutrition in the modulation of microbial composition and function in people with inflammatory bowel disease. Lancet Gastroenterol Hepatol, 6(9):754-769.

[20]WangHT, MaP, LiuPP, et al., 2021. lncRNA SNHG6 promotes hepatocellular carcinoma progression by interacting with HNRNPL/PTBP1 to facilitate SETD7/LZTFL1 mRNA destabilization. Cancer Lett, 520:121-131.

[21]WuF, HuangY, DongFS, et al., 2016. Ulcerative colitis-associated long noncoding RNA, BC012900, regulates intestinal epithelial cell apoptosis. Inflamm Bowel Dis, 22(4):782-795.

[22]YaraniR, MirzaAH, KaurS, et al., 2018. The emerging role of lncRNAs in inflammatory bowel disease. Exp Mol Med, 50(12):1-14.

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