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Multiple characteristic alterations and available therapeutic strategies of cellular senescence
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Yunzi ZHAO, Hui LI, Qinglong GUO, Hui HUI. Multiple characteristic alterations and available therapeutic strategies of cellular senescence[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Multiple characteristic alterations and available therapeutic strategies of cellular senescence",
author="Yunzi ZHAO, Hui LI, Qinglong GUO, Hui HUI",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200178"
}
%0 Journal Article
%T Multiple characteristic alterations and available therapeutic strategies of cellular senescence
%A Yunzi ZHAO
%A Hui LI
%A Qinglong GUO
%A Hui HUI
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200178
TY - JOUR
T1 - Multiple characteristic alterations and available therapeutic strategies of cellular senescence
A1 - Yunzi ZHAO
A1 - Hui LI
A1 - Qinglong GUO
A1 - Hui HUI
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200178
Abstract: Given its state of stable proliferative inhibition, cellular senescence is primarily depicted as a critical mechanism by which organisms delay the progression of carcinogenesis. Cells undergoing senescence are often associated with the alteration of a series of specific features and functions, such as metabolic shifts, stemness induction, and microenvironment remodeling. However, recent research has revealed more complexity associated with senescence, including adverse effects on both physiological and pathological processes. How organisms evade these harmful consequences and survive has become an urgent research issue. Several therapeutic strategies targeting senescence, including senolytics, senomorphics, immunotherapy, and function restoration, have achieved initial success in certain scenarios. In this review, we describe in detail the characteristic changes associated with cellular senescence and summarize currently available countermeasures.
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