CLC number:
On-line Access: 2023-10-12
Received: 2023-06-05
Revision Accepted: 2023-09-24
Crosschecked: 0000-00-00
Cited: 0
Clicked: 649
Weihao ZHENG, Qin ZHANG, Ziyang ZHAO, Pengfei ZHANG, Leilei ZHAO, Xiaomin WANG, Songyu YANG, Jing ZHANG, Zhijun YAO, Bin HU. Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder",
author="Weihao ZHENG, Qin ZHANG, Ziyang ZHAO, Pengfei ZHANG, Leilei ZHAO, Xiaomin WANG, Songyu YANG, Jing ZHANG, Zhijun YAO, Bin HU",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300401"
}
%0 Journal Article
%T Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder
%A Weihao ZHENG
%A Qin ZHANG
%A Ziyang ZHAO
%A Pengfei ZHANG
%A Leilei ZHAO
%A Xiaomin WANG
%A Songyu YANG
%A Jing ZHANG
%A Zhijun YAO
%A Bin HU
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300401
TY - JOUR
T1 - Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder
A1 - Weihao ZHENG
A1 - Qin ZHANG
A1 - Ziyang ZHAO
A1 - Pengfei ZHANG
A1 - Leilei ZHAO
A1 - Xiaomin WANG
A1 - Songyu YANG
A1 - Jing ZHANG
A1 - Zhijun YAO
A1 - Bin HU
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300401
Abstract: thalamocortical circuitry has a substantial impact on emotion and cognition. Previous studies have demonstrated alterations in thalamocortical functional connectivity (FC), characterized by region-dependent hypo- or hyper-connectivity, among individuals with major depressive disorder (MDD). However, the dynamical reconfiguration of the thalamocortical system over time and potential abnormalities in dynamic thalamocortical connectivity associated with MDD remain unclear. Hence, we analyzed dynamic FC (dFC) between ten thalamic subregions and seven cortical subnetworks from resting-state functional magnetic resonance images of 48 patients with MDD and 57 healthy controls (HCs) to investigate time-varying changes in thalamocortical FC in patients with MDD. Moreover, dynamic laterality analysis was conducted to examine the changes in functional lateralization of the thalamocortical system over time. Correlations between the dynamic measures of thalamocortical FC and clinical assessment were also calculated. We identified four dynamic states of thalamocortical circuitry wherein patients with MDD exhibited decreased fractional time and reduced transitions within a negative connectivity state that showed strong correlations with primary cortical networks, compared with the HCs. In addition, MDD patients also exhibited increased fluctuations in functional laterality in the thalamocortical system across the scan duration. The thalamo-subnetwork analysis unveiled abnormal dFC variability involving higher-order cortical networks in the MDD cohort. Significant correlations were found between increased dFC variability with dorsal attention and default mode networks and the severity of symptoms. Our study comprehensively investigated the pattern of alteration of the thalamocortical dFC in MDD patients. The heterogeneous alterations of dFC between the thalamus and both primary and higher-order cortical networks may help characterize the deficits of sensory and cognitive processing in MDD.
Open peer comments: Debate/Discuss/Question/Opinion
<1>