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Marwa A. DAHPY1,2, Ragaa H. SALAMA1, Abdel Raheim M.A. MEKI1,3, Ashraf Zein El-ABEDEEN4, Maiada K. HASHEM4, Ebtsam S. ABDULKAREEM5, Mohamed MOHANY6, Sinisa DJURASEVIC7, Amal N. IBRAHIM8, Nourhan M. HUSSEIN8 , Shima Gafar MANSOR9, Mohamed Ramadan IZZALDIN10, Marwa K. KHAIRALLAH11, Suzan Eid Elshishtawy IBRAHIM12, Alzahra ABDELBADEA13, Islam Khaled ali HARBY14, Fatma Y.A.ABBAS15, Rasha M. ALI15, Marwa A. SABET16, Salwa Seif ElDIN17, Abdelraouf M.S. ABDELRAOUF18, Amira A. KAMEL1. Potential relationship between circulating gene expression of ACE2, TLR4, and Il-17 and disease severity and out-come of COVID-19 hospitalized patients[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Potential relationship between circulating gene expression of ACE2, TLR4, and Il-17 and disease severity and out-come of COVID-19 hospitalized patients",
author="Marwa A. DAHPY1,2, Ragaa H. SALAMA1, Abdel Raheim M.A. MEKI1,3, Ashraf Zein El-ABEDEEN4, Maiada K. HASHEM4, Ebtsam S. ABDULKAREEM5, Mohamed MOHANY6, Sinisa DJURASEVIC7, Amal N. IBRAHIM8, Nourhan M. HUSSEIN8 , Shima Gafar MANSOR9, Mohamed Ramadan IZZALDIN10, Marwa K. KHAIRALLAH11, Suzan Eid Elshishtawy IBRAHIM12, Alzahra ABDELBADEA13, Islam Khaled ali HARBY14, Fatma Y.A.ABBAS15, Rasha M. ALI15, Marwa A. SABET16, Salwa Seif ElDIN17, Abdelraouf M.S. ABDELRAOUF18, Amira A. KAMEL1",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400345"
}
%0 Journal Article
%T Potential relationship between circulating gene expression of ACE2, TLR4, and Il-17 and disease severity and out-come of COVID-19 hospitalized patients
%A Marwa A. DAHPY1
%A 2
%A Ragaa H. SALAMA1
%A Abdel Raheim M.A. MEKI1
%A 3
%A Ashraf Zein El-ABEDEEN4
%A Maiada K. HASHEM4
%A Ebtsam S. ABDULKAREEM5
%A Mohamed MOHANY6
%A Sinisa DJURASEVIC7
%A Amal N. IBRAHIM8
%A Nourhan M. HUSSEIN8
%A Shima Gafar MANSOR9
%A Mohamed Ramadan IZZALDIN10
%A Marwa K. KHAIRALLAH11
%A Suzan Eid Elshishtawy IBRAHIM12
%A Alzahra ABDELBADEA13
%A Islam Khaled ali HARBY14
%A Fatma Y.A.ABBAS15
%A Rasha M. ALI15
%A Marwa A. SABET16
%A Salwa Seif ElDIN17
%A Abdelraouf M.S. ABDELRAOUF18
%A Amira A. KAMEL1
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400345
TY - JOUR
T1 - Potential relationship between circulating gene expression of ACE2, TLR4, and Il-17 and disease severity and out-come of COVID-19 hospitalized patients
A1 - Marwa A. DAHPY1
A1 - 2
A1 - Ragaa H. SALAMA1
A1 - Abdel Raheim M.A. MEKI1
A1 - 3
A1 - Ashraf Zein El-ABEDEEN4
A1 - Maiada K. HASHEM4
A1 - Ebtsam S. ABDULKAREEM5
A1 - Mohamed MOHANY6
A1 - Sinisa DJURASEVIC7
A1 - Amal N. IBRAHIM8
A1 - Nourhan M. HUSSEIN8
A1 - Shima Gafar MANSOR9
A1 - Mohamed Ramadan IZZALDIN10
A1 - Marwa K. KHAIRALLAH11
A1 - Suzan Eid Elshishtawy IBRAHIM12
A1 - Alzahra ABDELBADEA13
A1 - Islam Khaled ali HARBY14
A1 - Fatma Y.A.ABBAS15
A1 - Rasha M. ALI15
A1 - Marwa A. SABET16
A1 - Salwa Seif ElDIN17
A1 - Abdelraouf M.S. ABDELRAOUF18
A1 - Amira A. KAMEL1
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2400345
Abstract: acute respiratory distress syndrome (ARDS) is a form of progressive hypoxemia that can be brought on by a variety of cardiorespiratory or systemic disorders, such as COVID-19. The binding of a SARS-Cov-2 virus spike protein to the cell membrane is mediated through its binding to the ACE2 receptors, resulting in viral entry, replication, and induction of a signaling cascade inducing pro-inflammatory responses that are linked to a higher mortality rate and the progression of ARDS, leading to multi-organ failure in these patients. We aimed to analyze the relationship between ACE2, TLR4, and Il-17 circulating gene-expression levels and the clinical severity of COVID-19 disease, as well as the associated pathogenic condition of hospitalized patients. Sixty COVID-19 patients (34 mild/moderate and 26 with severe ARDS manifestation) and 60 healthy controls were included. The patient group was also subdivided according to outcomes into 32 recoveries and 28 deaths. ACE2, TLR-4, and IL-17 levels were assessed by qPCR in addition to all routine baseline laboratory investigations, including CBC with differential analysis, CRP, ferritin, and D-dimer. ACE2, TLR-4, and IL-17 serum expression levels were significantly higher in the COVID-19 group and subgroups and correlated with different laboratory and clinical parameters. The serum expression levels of ACE2, TLR-4, and IL-17 were accurate in differentiating between the patient groups and controls with 86.7%, 91.7%, and 95% sensitivity and 96.7%, 98.3%, and 98.3% specificity, respectively, and correlate to more severe disease courses in COVID-19 patients. Higher levels are associated with overwhelmingly distressing outcomes.
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