CLC number: TP212.3
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2014-04-11
Cited: 6
Clicked: 10091
Jing-jing Wang, Wei-hui Liu, Da Chen, Yan Xu, Lu-yin Zhang. A micro-machined thin film electro-acoustic biosensor for detection of pesticide residuals[J]. Journal of Zhejiang University Science C, 2014, 15(5): 383-389.
@article{title="A micro-machined thin film electro-acoustic biosensor for detection of pesticide residuals",
author="Jing-jing Wang, Wei-hui Liu, Da Chen, Yan Xu, Lu-yin Zhang",
journal="Journal of Zhejiang University Science C",
volume="15",
number="5",
pages="383-389",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.C1300289"
}
%0 Journal Article
%T A micro-machined thin film electro-acoustic biosensor for detection of pesticide residuals
%A Jing-jing Wang
%A Wei-hui Liu
%A Da Chen
%A Yan Xu
%A Lu-yin Zhang
%J Journal of Zhejiang University SCIENCE C
%V 15
%N 5
%P 383-389
%@ 1869-1951
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.C1300289
TY - JOUR
T1 - A micro-machined thin film electro-acoustic biosensor for detection of pesticide residuals
A1 - Jing-jing Wang
A1 - Wei-hui Liu
A1 - Da Chen
A1 - Yan Xu
A1 - Lu-yin Zhang
J0 - Journal of Zhejiang University Science C
VL - 15
IS - 5
SP - 383
EP - 389
%@ 1869-1951
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.C1300289
Abstract: Increasing awareness concerning food safety problems has been driving the search for simple and efficient biochemical analytical methods. In this paper, we develop a portable electro-acoustic biosensor based on a film bulk acoustic resonator for the detection of pesticide residues in agricultural products. A shear mode ZnO film bulk acoustic resonator with a micro-machining structure was fabricated as a mass-sensitive transducer for the real-time detection of antibody-antigen reactions in liquids. In order to obtain an ultra-low detection level, the artificial antigens were immobilized on the sensing surface of the resonator to employ a competitive format for the immunoassays. The competitive immunoreactions can be observed clearly through monitoring the frequency changes. The presence of pesticides was detected through the diminution of the frequency shift compared with the level without pesticides. The limit of detection for carbaryl (a widely used pesticide for vegetables and crops) is 2×10−10 M. The proposed device represents a potential alternative to the complex optical systems and electrochemical methods that are currently being used, and represents a significant opportunity in terms of simplicity of use and portability for on-site food safety testing.
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