JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE BDM

Accepted manuscript available online (unedited version)

Concurrent bioprinted scaffold with autologous bone and allogeneic BMSCs promote bone regeneration via recuiting native BMSCs

Author(s): Yu Huan, Hongqing Chen, Dezhi Zhou, Xin He, Sanzhong Li, Xiuquan Wu, Bo Jia, Yanan Dou, Xiaowei Fei, Shuang Wu, Zhou Fei, Tao Xu, Fei Fei
Affiliation(s): Department of Neurosurgery, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China;Department of Neurosurgery, General Hospital of Northern Theater Command, Shenyang 110840, China.;Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.;Key Laboratory for Advanced Materials Processing Technology, Ministry of Education, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China.;Department of Precision Medicine and Healthcare, Tsinghua-Berkeley Shenzhen Institute, Shenzhen 518055, China.;Center for Bio-intelligent Manufacturing and Living Matter Bioprinting, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, China.;Department of Ophthalmology, Xijing Hospital, Air Force Medical University, Xi'an, 710032, China.
Corresponding email(s): feeplus@163.com, xut@tsinghua-sz.org, feizhou@fmmu.edu.cn
Key Words:

Share this article to： More

Yu Huan, Hongqing Chen, Dezhi Zhou, Xin He, Sanzhong Li, Xiuquan Wu, Bo Jia,Yanan Dou, Xiaowei Fei, Shuang Wu, Zhou Fei, Tao Xu,Fei Fei. Concurrent bioprinted scaffold with autologous bone and allogeneic BMSCs promote bone regeneration via recuiting native BMSCs[J]. Journal of Zhejiang University Science BDM,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1007/s42242-BDMJ-D-24-00011

@article{title="Concurrent bioprinted scaffold with autologous bone and allogeneic BMSCs promote bone regeneration via recuiting native BMSCs",
author="Yu Huan, Hongqing Chen, Dezhi Zhou, Xin He, Sanzhong Li, Xiuquan Wu, Bo Jia,Yanan Dou, Xiaowei Fei, Shuang Wu, Zhou Fei, Tao Xu,Fei Fei",
journal="Journal of Zhejiang University Science BDM",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1007/s42242-BDMJ-D-24-00011"
}

%0 Journal Article
%T Concurrent bioprinted scaffold with autologous bone and allogeneic BMSCs promote bone regeneration via recuiting native BMSCs
%A Yu Huan
%A Hongqing Chen
%A Dezhi Zhou
%A Xin He
%A Sanzhong Li
%A Xiuquan Wu
%A Bo Jia
%A Yanan Dou
%A Xiaowei Fei
%A Shuang Wu
%A Zhou Fei
%A Tao Xu
%A Fei Fei
%J Journal of Zhejiang University SCIENCE BDM
%P
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1007/s42242-BDMJ-D-24-00011"

TY - JOUR
T1 - Concurrent bioprinted scaffold with autologous bone and allogeneic BMSCs promote bone regeneration via recuiting native BMSCs
A1 - Yu Huan
A1 - Hongqing Chen
A1 - Dezhi Zhou
A1 - Xin He
A1 - Sanzhong Li
A1 - Xiuquan Wu
A1 - Bo Jia
A1 - Yanan Dou
A1 - Xiaowei Fei
A1 - Shuang Wu
A1 - Zhou Fei
A1 - Tao Xu
A1 - Fei Fei
J0 - Journal of Zhejiang University Science BDM
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1007/s42242-BDMJ-D-24-00011"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Autologous bone marrow-derived mesenchymal stem cells (BMSCs) have been shown to promote osteogenesis; however, whether allogeneic BMSCs (Allo-BMSCs) have effects on bone regeneration is not clear. Therefore, we explored the effect of Allo-BMSCs on promoting bone regeneration in 3D-printed autologous bone (AB) scaffolds. Firstly, we concurrently printed scaffolds with polycaprolactone, AB particles (ABP) and Allo-BMSCs for appropriate support, providing bioactive factors and seed cells to promote osteogenesis. In vitro studies showed that AB scaffolds promoted the osteogenic differentiation of Allo-BMSCs. In vivo studies revealed that implantation of scaffolds loaded with ABP and Allo-BMSCs into canine skull defects for 9 months promoted osteogenesis. Further studies suggested that only a small portion of implanted Allo-BMSCs survived and became the vascular endothelial cell, chondrocyte, and osteocyte, and the implanted Allo-BMSCs released stromal cell-derived factor 1 through paracrine signaling to recruit native BMSCs into the defect, promoting bone regeneration. This study provides additional opportunities for the future uses of Allo-BMSCs.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

Open peer comments: Debate/Discuss/Question/Opinion

<1>

- Go to

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference