JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Polypeptide-modified BP nanosheets as a brain-targeted neuroprotective agent for treating ischemic stroke

Author(s): Meili Zhang, Taojian Fan, Shujiang Yin, Jie Li, Jing Hou, Ke Zhang, Bo Han, Wen Chen, Han Zhang, Xing Tian
Affiliation(s): Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, College of Pharmacy, Shihezi University, Shihezi, 832002, China; Institute of Microscale Optoelectronics, Collaborative Innovation Centre for Optoelectronic Science & Technology, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology, Guangdong Laboratory of Artificial Intelligence and Digital Economy (SZ), Shenzhen University, Shenzhen, 518060, PR China; Corresponding author. Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, Shenzhen University, Shenzhen, 518060, China.; Corresponding author. Key Laboratory of Xinjiang Phytomedicine Resources and Utilization of Ministry of Education, School of Pharmacy, Shihezi University, Shihezi, 832000, China
Corresponding email(s): hzhang@szu.edu.cn, tianxingdeyoujian@163.com
Key Words: Black phosphorus nanosheets; Resveratrol; Polypeptide; Ischemic stroke; Blood-brain barrier; Drug delivery system

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Meili Zhang, Taojian Fan, Shujiang Yin, Jie Li, Jing Hou, Ke Zhang, Bo Han, Wen Chen, Han Zhang, Xing Tian. Polypeptide-modified BP nanosheets as a brain-targeted neuroprotective agent for treating ischemic stroke[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/bdm.2400175

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author="Meili Zhang, Taojian Fan, Shujiang Yin, Jie Li, Jing Hou, Ke Zhang, Bo Han, Wen Chen, Han Zhang, Xing Tian",
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doi="https://doi.org/10.1631/bdm.2400175"
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doi="https://doi.org/10.1631/bdm.2400175"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Ischemic stroke is the leading cause of death in China, accounting for approximately one-third of all stroke-associated deaths worldwide. Currently, thrombolysis is employed for Preprint of Bio-Design and Manufacturing (unedited) ischemic strokes. However, due to the limited therapeutic window of thrombolytic agents, most patients do not receive the drug at the right time. Moreover, these agents are associated with risks of hemorrhage and reperfusion damage. Herein, ANG-BP-RES, a drug-loaded system, was used to deliver drugs across the blood-brain barrier (BBB). ANG-BP-RES has a uniform size, stable structure, good photothermal effect, and strong drug release ability under near-infrared (NIR) irradiation and acidic conditions. Furthermore, ANG-BP-RES can efficiently target the brain and improve BBB permeability, exerting a significant therapeutic effect against ischemic brain injury, especially after NIR radiation. ANG-BP-RES is also biocompatible and shows minimal toxicity toward cells and tissues. This study offers novel insights into the therapeutic management of ischemic brain injury.

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