JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

A design strategy developed for long term stability of porous PEEK implants through the combined regulation of porous structure and in vivo mechanical stimulation

Author(s): Yingjie Liu , Ling Wang，Jie Zhang , Shuguang Liu , Jibao Zheng , Jianfeng Kang , Enchun Dong , Changning Sun , Ruhan A , Chaozong Liu , Chuncheng Yang, Dichen Li
Affiliation(s): State Key Laboratory for Manufacturing System Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi, China; National Medical Products Administration (NMPA) Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices, Xi'an Jiaotong University, 710054, Xi'an, ShaanXi, China; Academy of Orthopedics, Guangdong Province, Orthopaedic Hospital of Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China; Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; School of Mechatronic Engineering and Automation, Foshan University, Foshan, 528225, China; Center for Medical Device Evaluation of NMPA, Beijing, China; Institute of Orthopaedic & Musculoskeletal, University College London, Royal National Orthopaedic Hospital, Stanmore, UK; Shaanxi Jukang Gobo Medical Technology Co.,Ltd., Xi'an, Shaanxi, China
Corresponding email(s): menlwang@xjtu.edu.cn, dcli@xjtu.edu.cn
Key Words: Porous PEEK implant, osteointegration, interface biomechanics, maxillofacial implants, Finite Element Analyses, FFF 3D printing

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Yingjie Liu , Ling Wang，Jie Zhang , Shuguang Liu , Jibao Zheng , Jianfeng Kang , Enchun Dong , Changning Sun , Ruhan A , Chaozong Liu , Chuncheng Yang, Dichen Li. A design strategy developed for long term stability of porous PEEK implants through the combined regulation of porous structure and in vivo mechanical stimulation[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/bdm.2400259

@article{title="A design strategy developed for long term stability of porous PEEK implants through the combined regulation of porous structure and in vivo mechanical stimulation",
author="Yingjie Liu , Ling Wang，Jie Zhang , Shuguang Liu , Jibao Zheng , Jianfeng Kang , Enchun Dong , Changning Sun , Ruhan A , Chaozong Liu , Chuncheng Yang, Dichen Li",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/bdm.2400259"
}

%0 Journal Article
%T A design strategy developed for long term stability of porous PEEK implants through the combined regulation of porous structure and in vivo mechanical stimulation
%A Yingjie Liu
%A Ling Wang，Jie Zhang
%A Shuguang Liu
%A Jibao Zheng
%A Jianfeng Kang
%A Enchun Dong
%A Changning Sun
%A Ruhan A
%A Chaozong Liu
%A Chuncheng Yang
%A Dichen Li
%J Journal of Zhejiang University SCIENCE B
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%@ 2095-9184
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/bdm.2400259"

TY - JOUR
T1 - A design strategy developed for long term stability of porous PEEK implants through the combined regulation of porous structure and in vivo mechanical stimulation
A1 - Yingjie Liu
A1 - Ling Wang，Jie Zhang
A1 - Shuguang Liu
A1 - Jibao Zheng
A1 - Jianfeng Kang
A1 - Enchun Dong
A1 - Changning Sun
A1 - Ruhan A
A1 - Chaozong Liu
A1 - Chuncheng Yang
A1 - Dichen Li
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 2095-9184
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/bdm.2400259"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: The bioinert nature of PEEK material limits the widespread clinical application of PEEK implants. Although the porous structure is believed to improve the osseointegration performance of PEEK implants, it is hardly used due to the decreased mechanical properties. This study investigates the combined influence of the porous structure and the in vivo mechanical stimulation on implantation safety and bone growth based on the finite element analysis of the biomechanical behavior of the implantation system. It is shown that with the combined control of pore size and screw preloads, the porous PEEK implant can achieve good osseointegration while maintain a relatively high safety level. The optimal combination of pore size and the screw preload are derived. With the pore size of 600 μm and the preload of 0.05 N·m, the safety factor of the implant exceeds 2, and the predicted percentage of the effective bone growth area of the bone-implant interface reaches 97%. The PEEK implants were fabricated by FFF 3D printing technique for further clinical applications. The clinical outcomes demonstrated the better bone repair efficacy and long-term stability of the porous PEEK implants compared to the solid PEEK implants. Good osteointegration performance of the 3D printed porous PEEK implants was shown with the average BV/TV exceeding 40% 3 months after implantation. In conclusion, the 3D printed porous PEEK implants have great potential for clinical application with validated implantation safety and good osseointegration.

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