JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis

Author(s): Huiya FANG, Jin LIN, Yiwu QIU, Zijian CHENG, Weiqian CHEN
Affiliation(s): Division of Rheumatology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang, China; more
Corresponding email(s): zj_cheng@zju.edu.cn, cwq678@zju.edu.cn
Key Words: Rheumatoid arthritis; Periodontitis; Pathogenesis; Citrullination; ACPA

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Huiya FANG, Jin LIN, Yiwu QIU, Zijian CHENG, Weiqian CHEN. Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300519

@article{title="Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis",
author="Huiya FANG, Jin LIN, Yiwu QIU, Zijian CHENG, Weiqian CHEN",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300519"
}

%0 Journal Article
%T Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis
%A Huiya FANG
%A Jin LIN
%A Yiwu QIU
%A Zijian CHENG
%A Weiqian CHEN
%J Journal of Zhejiang University SCIENCE B
%P
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2300519"

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T1 - Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis
A1 - Huiya FANG
A1 - Jin LIN
A1 - Yiwu QIU
A1 - Zijian CHENG
A1 - Weiqian CHEN
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B2300519"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Rheumatoid arthritis (RA), an autoimmune disease characterized by chronic inflammation of synovial tissue, is divided into two subtypes—anticitrullinated protein antibodies (ACPA)-positive and ACPA-negative RA. While the pathogenic mechanisms of ACPA-positive RA are well-understood, the etiology of ACPA-negative RA remains largely unknown. The association between RA and periodontitis (PD) has been observed since the early 1900s, with the two diseases sharing common genetic and environmental risk factors that lead to the progressive destruction of bone and connective tissue. However, the association between PD and the two subtypes of RA is different. This comprehensive review aims to provide an updated understanding of the epidemiological association between RA and PD, explore potential pathogenic mechanisms linking the two diseases, and highlight the key distinctions between the subtypes of RA and their respective associations with PD. We also discuss the possibility of early intervention or the treatment of the two diseases. Ultimately, this review aims to provide valuable insights for future research in this field.

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