JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives

Author(s): Xiaoyu HAN, Peijun LI, Meiling JIANG, Yuanyuan CAO, Yingqi WANG, Linhong JIANG, Xiaodan LIU, Weibing WU
Affiliation(s): Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China; more
Corresponding email(s): wwb75@126.com, hzhp403@126.com
Key Words: Autophagy; Skeletal muscle dysfunction; Chronic obstructive pulmonary disease; Mitochondria; Muscle satellite cells

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Xiaoyu HAN, Peijun LI, Meiling JIANG, Yuanyuan CAO, Yingqi WANG, Linhong JIANG, Xiaodan LIU, Weibing WU. Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300680

@article{title="Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives",
author="Xiaoyu HAN, Peijun LI, Meiling JIANG, Yuanyuan CAO, Yingqi WANG, Linhong JIANG, Xiaodan LIU, Weibing WU",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300680"
}

%0 Journal Article
%T Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives
%A Xiaoyu HAN
%A Peijun LI
%A Meiling JIANG
%A Yuanyuan CAO
%A Yingqi WANG
%A Linhong JIANG
%A Xiaodan LIU
%A Weibing WU
%J Journal of Zhejiang University SCIENCE B
%P
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2300680"

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T1 - Autophagy in skeletal muscle dysfunction of chronic obstructive pulmonary disease: implications, mechanisms, and perspectives
A1 - Xiaoyu HAN
A1 - Peijun LI
A1 - Meiling JIANG
A1 - Yuanyuan CAO
A1 - Yingqi WANG
A1 - Linhong JIANG
A1 - Xiaodan LIU
A1 - Weibing WU
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300680"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Skeletal muscle dysfunction is a common extrapulmonary comorbidity of chronic obstructive pulmonary disease (COPD) and is associated with decreased quality-of-life and survival in patients. The autophagy lysosome pathway is one of the proteolytic systems that significantly affects skeletal muscle structure and function. Intriguingly, both promoting and inhibiting autophagy have been observed to improve COPD skeletal muscle dysfunction, yet the mechanism is unclear. This paper first reviewed the effects of macroautophagy and mitophagy on the structure and function of skeletal muscle in COPD, and then explored the mechanism of autophagy mediating the dysfunction of skeletal muscle in COPD. The results showed that macroautophagy- and mitophagy-related proteins were significantly increased in COPD skeletal muscle. Promoting macroautophagy in COPD improves myogenesis and replication capacity of muscle satellite cells, while inhibiting macroautophagy in COPD myotubes increases their diameters. Mitophagy helps to maintain mitochondrial homeostasis by removing impaired mitochondria in COPD. Autophagy is a promising target for improving COPD skeletal muscle dysfunction, and further research should be conducted to elucidate the specific mechanisms by which autophagy mediates COPD skeletal muscle dysfunction, with the aim of enhancing our understanding in this field.

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