JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

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Association between post-COVID-19 sleep disturbance and neurocognitive function: a comparative study based on propensity score matching

Author(s): Shixu DU, Leqin FANG, Yuanhui LI, Shuai LIU, Xue LUO, Shufei ZENG, Shuqiong ZHENG, Hangyi YANG, Yan XU, Dai LI, Bin ZHANG
Affiliation(s): Department of Psychiatry, Sleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; more
Corresponding email(s): zhang73bin@hotmail.com
Key Words: Coronavirus disease 2019 (COVID-19); Post-COVID-19; Sleep disturbance; Neurocognitive function; Digital assessment

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Shixu DU, Leqin FANG, Yuanhui LI, Shuai LIU, Xue LUO, Shufei ZENG, Shuqiong ZHENG, Hangyi YANG, Yan XU, Dai LI, Bin ZHANG. Association between post-COVID-19 sleep disturbance and neurocognitive function: a comparative study based on propensity score matching[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300831

@article{title="Association between post-COVID-19 sleep disturbance and neurocognitive function: a comparative study based on propensity score matching",
author="Shixu DU, Leqin FANG, Yuanhui LI, Shuai LIU, Xue LUO, Shufei ZENG, Shuqiong ZHENG, Hangyi YANG, Yan XU, Dai LI, Bin ZHANG",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300831"
}

%0 Journal Article
%T Association between post-COVID-19 sleep disturbance and neurocognitive function: a comparative study based on propensity score matching
%A Shixu DU
%A Leqin FANG
%A Yuanhui LI
%A Shuai LIU
%A Xue LUO
%A Shufei ZENG
%A Shuqiong ZHENG
%A Hangyi YANG
%A Yan XU
%A Dai LI
%A Bin ZHANG
%J Journal of Zhejiang University SCIENCE B
%P 172-184
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2300831"

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A1 - Shixu DU
A1 - Leqin FANG
A1 - Yuanhui LI
A1 - Shuai LIU
A1 - Xue LUO
A1 - Shufei ZENG
A1 - Shuqiong ZHENG
A1 - Hangyi YANG
A1 - Yan XU
A1 - Dai LI
A1 - Bin ZHANG
J0 - Journal of Zhejiang University Science B
SP - 172
EP - 184
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300831"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Despite that sleep disturbance and poor neurocognitive performance are common complaints among coronavirus disease 2019 (COVID-19) survivors, few studies have focused on the effect of post-COVID-19 sleep disturbance (PCSD) on cognitive function. This study aimed to identify the impact of PCSD on neurocognitive function and explore the associated risk factors for the worsening of this condition. This cross-sectional study was conducted via the web-based assessment in Chinese mainland. Neurocognitive function was evaluated by the modified online Integrated Cognitive Assessment (ICA) and the Number Ordering Test (NOT). Propensity score matching (PSM) was utilized to match the confounding factors between individuals with and without PCSD. Univariate analyses were performed to evaluate the effect of PCSD on neurocognitive function. The risk factors associated with worsened neurocognitive performance in PCSD individuals were explored using binary logistic regression. A total of 8692 individuals with COVID-19 diagnosis were selected for this study. Nearly half (48.80%) of the COVID-19 survivors reported sleep disturbance. After matching by PSM, a total of 3977 pairs (7954 individuals in total) were obtained. Univariate analyses revealed that PCSD was related to worse ICA and NOT performance (P<0.05). Underlying disease, upper respiratory infection, loss of smell or taste, severe pneumonia, and self-reported cognitive complaints were associated with worsened neurocognitive performance among PCSD individuals (P<0.05). Furthermore, aging, ethnicity (minority), and lower education level were found to be independent risk factors for worsened neurocognitive performance in PCSD individuals (P<0.05). PCSD was related to impaired neurocognitive performance. Therefore, appropriate prevention and intervention measures should be taken to minimize or prevent PCSD and eliminate its potential adverse effect on neurocognitive function.

COVID-19后睡眠紊乱与神经认知功能之间的关系：基于倾向评分匹配方法的研究

杜适序^1,2，方乐琴^1,2，李元辉³，刘帅^1,2，罗雪^1,2，曾淑妃^1,2，郑舒琼^1,2，杨航怡^1,2，许艳^1,2，李岱³，张斌^1,2
¹南方医科大学南方医院精神心理科（睡眠医学中心），中国广州市，510515
²精神健康研究教育部重点实验室，中国广州市，510515
³阿呆科技（北京）有限公司，中国北京市，100083
摘要：睡眠紊乱和神经认知功能减退是2019冠状病毒病（COVID-19）幸存者常见的主诉，然而既往少有研究关注COVID-19后睡眠紊乱（PCSD）对认知功能的影响。本研究旨在确定PCSD对神经认知功能的影响，并探讨与较差的神经认知功能相关的危险因素。本研究是一项在中国进行的基于网络评估的横断面研究，通过改良版在线综合认知评估（ICA）和数字排序测试（NOT）对神经认知功能进行评估。我们使用倾向性评分匹配（PSM）的方法平衡PCSD组及非PCSD组受试者之间的混杂因素，使用单因素分析评估PCSD对神经认知功能的影响，并使用二元logistic回归探索与较差的神经认知表现相关的危险因素。本研究共纳入8692名COVID-19幸存者，其中48.80%的COVID-19幸存者报告有睡眠紊乱。PSM后匹配了3977对（总共7954名受试者）。单因素分析显示PCSD与更差的ICA和NOT表现相关（P<0.05）。研究结果表明，基础疾病、上呼吸道感染、嗅觉或味觉丧失、严重肺炎和自我报告的认知障碍与PCSD受试者的神经认知功能的恶化相关（P<0.05）；此外，年龄、少数民族和较低的教育水平是PCSD受试者中较差的神经认知表现的独立风险因素（P<0.05）。总之，PCSD与较差的神经认知功能表现相关，我们应该采取适当的预防和干预措施来减少或预防PCSD对神经认知功能产生的潜在不良影响。

关键词组：2019冠状病毒病（COVID-19）；COVID-19感染后；睡眠紊乱；神经认知功能；数字评估

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COVID-19后睡眠紊乱与神经认知功能之间的关系：基于倾向评分匹配方法的研究

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