JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Energy deprivation-induced Autophagy and Aggrephagy: insights from yeast and mammals

Author(s): Siyu FAN, Yingcong CHEN, Weijing YAO, Cong YI
Affiliation(s): Department of Biochemistry, and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Corresponding email(s): yiconglab@zju.edu.cn
Key Words: Autophagy; Glucose starvation; Solid aggrephagy; CCT2

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Siyu FAN, Yingcong CHEN, Weijing YAO, Cong YI. Energy deprivation-induced Autophagy and Aggrephagy: insights from yeast and mammals[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300884

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author="Siyu FAN, Yingcong CHEN, Weijing YAO, Cong YI",
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year="in press",
publisher="Zhejiang University Press & Springer",
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%T Energy deprivation-induced Autophagy and Aggrephagy: insights from yeast and mammals
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%A Yingcong CHEN
%A Weijing YAO
%A Cong YI
%J Journal of Zhejiang University SCIENCE B
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doi="https://doi.org/10.1631/jzus.B2300884"

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A1 - Weijing YAO
A1 - Cong YI
J0 - Journal of Zhejiang University Science B
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doi="https://doi.org/10.1631/jzus.B2300884"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli. However, compared to research on nutrient deprivation-induced autophagy, the understanding of the molecular mechanisms and physiological/ pathological significance of autophagy triggered by energy deprivation remains limited. A primary focus of our lab is to elucidate how cells sense energy deprivation and initiate autophagy. Using the model organisms Saccharomyces cerevisiae and mammals, we have made a series of significant discoveries in this area. This review aims to provide a concise overview of these research findings.

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