JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

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A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis

Author(s): Jinya LIN, Rending WANG, Yuanyuan ZHU, Weijia HUANG, Jie SUN
Affiliation(s): Bone Marrow Transplantation Centre, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more
Corresponding email(s): jsun1492@gmail.com
Key Words: Eosinophilic granulomatosis with polyangiitis (EGPA); Idiopathic hypereosinophilic syndrome (I-HES); Cardiac arrest; Spontaneous renal hemorrhage

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Jinya LIN, Rending WANG, Yuanyuan ZHU, Weijia HUANG, Jie SUN. A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300940

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author="Jinya LIN, Rending WANG, Yuanyuan ZHU, Weijia HUANG, Jie SUN",
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doi="https://doi.org/10.1631/jzus.B2300940"
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%T A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis
%A Jinya LIN
%A Rending WANG
%A Yuanyuan ZHU
%A Weijia HUANG
%A Jie SUN
%J Journal of Zhejiang University SCIENCE B
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doi="https://doi.org/10.1631/jzus.B2300940"

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T1 - A case of cardiac arrest and spontaneous renal hemorrhage in a male patient with persistent eosinophilia: highlighting the importance of early diagnosis of eosinophilic granulomatosis with polyangiitis
A1 - Jinya LIN
A1 - Rending WANG
A1 - Yuanyuan ZHU
A1 - Weijia HUANG
A1 - Jie SUN
J0 - Journal of Zhejiang University Science B
SP - 708
EP - 712
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PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300940"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare multi-system disease that presents significant diagnostic challenges due to its complexity and low incidence (White and Dubey, 2023). It affects males and females equally, though males may exhibit more active disease at diagnosis and often require more aggressive treatment (Liu et al., 2023). The hallmark features of EGPA include delayed-onset asthma, eosinophilia in tissues and blood, and vasculitis affecting small to medium-sized arteries (White and Dubey, 2023). EGPA falls under the category of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), whereas only about half of EGPA patients test positive for ANCA (Khoury et al., 2023).

一例男性患者因持续性嗜酸性粒细胞增多导致心脏骤停及自发性肾出血的病例报告：强调嗜酸性肉芽肿性多血管炎早期诊断的重要性

林瑾娅¹，王仁定²，朱园园¹，黄维加¹，孙洁¹
¹浙江大学医学院附属第一医院骨髓移植中心，中国杭州市，310003
²浙江大学医学院附属第一医院肾脏病中心，中国杭州市，310003
摘要：嗜酸性肉芽肿性多血管炎（EGPA）是一种罕见的多系统性疾病，其诊断充满挑战，尤其是在病情复杂且发病率低的情况下。本文报告了一例58岁男性患者，既往有10年哮喘病史和1年特发性嗜酸性粒细胞增多症（I-HES）病史。患者因持续性嗜酸性粒细胞增多并伴随心脏骤停和自发性肾出血（SRH）而住院治疗。经心肺复苏后，患者因肾破裂出血接受了右肾切除术，肾脏活检结果显示血管闭塞及嗜酸性粒细胞浸润，最终确诊为EGPA。患者在糖皮质激素和免疫抑制剂联合治疗后取得显著疗效。本文强调了早期识别和及时干预在EGPA管理中的重要性。

关键词组：嗜酸性肉芽肿性多血管炎（EGPA）；特发性嗜酸性粒细胞增多症（I-HES）；心脏骤停；自发性肾出血（SRH）

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一例男性患者因持续性嗜酸性粒细胞增多导致心脏骤停及自发性肾出血的病例报告：强调嗜酸性肉芽肿性多血管炎早期诊断的重要性

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