JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia

Author(s): Ziyin YANG, Lei HAI, Xiaoyu CHEN, Siwen WU, Yan LV, Dawei CUI, Jue XIE
Affiliation(s): Department of Blood Transfusion, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Corresponding email(s): daweicui@zju.edu.cn, zyyyxj2011@zju.edu.cn
Key Words: OX40L; OX40; Immune thrombocytopenia; Follicular T helper cell; B cell

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Ziyin YANG, Lei HAI, Xiaoyu CHEN, Siwen WU, Yan LV, Dawei CUI, Jue XIE. OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300947

@article{title="OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia",
author="Ziyin YANG, Lei HAI, Xiaoyu CHEN, Siwen WU, Yan LV, Dawei CUI, Jue XIE",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300947"
}

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%T OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia
%A Ziyin YANG
%A Lei HAI
%A Xiaoyu CHEN
%A Siwen WU
%A Yan LV
%A Dawei CUI
%A Jue XIE
%J Journal of Zhejiang University SCIENCE B
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%@ 1673-1581
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%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2300947"

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T1 - OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia
A1 - Ziyin YANG
A1 - Lei HAI
A1 - Xiaoyu CHEN
A1 - Siwen WU
A1 - Yan LV
A1 - Dawei CUI
A1 - Jue XIE
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2300947"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Immune thrombocytopenia (ITP) is a hemorrhagic autoimmune disease characterized by antibody-mediated platelet injury. ITP has complicated immunopathological mechanisms that need further elucidation. It is well known that the costimulatory molecules OX40L and OX40 play essential roles in the immunological mechanisms of autoimmune diseases. Previously, we discovered that the expression of OX40L and OX40 is significantly increased in the PBMCs of ITP patients. In our present study, OX40L-induced Tfh cells exhibited an activated phenotype with elevated ICOS, PD-1, and CD40L expression in vitro. Moreover, aberrant OX40L-OX40 expression might promote the Tfh1-to-Tfh2 shift in vivo, inducing the generation of autoantibodies by enhancing the helper function of Tfh cells for B lymphocytes in a mouse model, which might accelerate the progression of ITP. Additionally, signal transduction through the OX40L-OX40 axis might be related to the activation of TRAF-NF-κB and JAK-STAT signaling pathways. Overall, OX40L-OX40 signaling is proposed as a potential novel therapeutic target for ITP.

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