JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Recent research advances in the biological function and molecular mechanism of methylmalonic acid

Author(s): Ziang WANG, Teng WANG, Yidi ZHANG, Wenhui CHENG, Xin'e SHI, Yuqi LV, Jianjun JIN
Affiliation(s): Laboratory of Animal Fat Deposition and Muscle Development, Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China; more
Corresponding email(s): jinjianjun2021@nwafu.edu.cn, lvyuqi@nwafu.edu.cn
Key Words: Methylmalonic acid; Mitochondrial dysfunction; Oxidative stress; Post-translational modification of proteins; Muscle atrophy

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Ziang WANG, Teng WANG, Yidi ZHANG, Wenhui CHENG, Xin'e SHI, Yuqi LV, Jianjun JIN. Recent research advances in the biological function and molecular mechanism of methylmalonic acid[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2400202

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author="Ziang WANG, Teng WANG, Yidi ZHANG, Wenhui CHENG, Xin'e SHI, Yuqi LV, Jianjun JIN",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2400202"
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%T Recent research advances in the biological function and molecular mechanism of methylmalonic acid
%A Ziang WANG
%A Teng WANG
%A Yidi ZHANG
%A Wenhui CHENG
%A Xin'e SHI
%A Yuqi LV
%A Jianjun JIN
%J Journal of Zhejiang University SCIENCE B
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%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2400202"

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T1 - Recent research advances in the biological function and molecular mechanism of methylmalonic acid
A1 - Ziang WANG
A1 - Teng WANG
A1 - Yidi ZHANG
A1 - Wenhui CHENG
A1 - Xin'e SHI
A1 - Yuqi LV
A1 - Jianjun JIN
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2400202"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: The abnormal accumulation of methylmalonic acid (MMA), the leading cause of methylmalonic acidemia, can cause irreversible damage to the brain, kidney and cardiovascular system. In addition, the accumulation of MMA in the blood has recently been associated with the occurrence of cancer, restricted bodily movement and growth retardation. In this review, recent studies on the relationship between the metabolic abnormality of MMA and disease occurrence were summarized concerning the brain, kidney, cardiovascular system, cancer, and skeletal muscles, providing a theoretical basis and reference for further research and the treatment of MMA-related pathophysiological changes.

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