JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Role of Wnt ligands and receptors in oral squamous cell carcinoma

Author(s): Muhammad TUFAIL, Cai-Yun HE, Can-Hua JIANG, Ning LI
Affiliation(s): Department of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha 410008 China; more
Corresponding email(s): liningoms@csu.edu.cn
Key Words: Oral squamous cell carcinoma; Wnt signaling; Molecular mechanisms; Tumorigenesis; Therapeutic targets

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Muhammad TUFAIL, Cai-Yun HE, Can-Hua JIANG, Ning LI. Role of Wnt ligands and receptors in oral squamous cell carcinoma[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2400251

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author="Muhammad TUFAIL, Cai-Yun HE, Can-Hua JIANG, Ning LI",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2400251"
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doi="https://doi.org/10.1631/jzus.B2400251"

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doi="https://doi.org/10.1631/jzus.B2400251"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Oral squamous cell carcinoma (OSCC) poses significant challenges in terms of diagnosis and treatment, with high rates of morbidity and mortality. Emerging evidence highlights the critical involvement of Wnt ligands and receptors in OSCC patho-genesis. Dysregulated Wnt signaling pathways' contribution to tumor initiation, progression, and therapy resistance is character-ized by their ability to promote cellular proliferation, epithelial-mesenchymal transition (EMT), and the maintenance of cancer stem cells (CSCs). Targeting Wnt signaling presents a promising therapeutic avenue, yet its complex interplay with other signaling pathways requires a deeper understanding to implement effective intervention. This study sheds light on the current knowledge of the role of Wnt ligands and receptors in OSCC, emphasizing their potential as diagnostic biomarkers and therapeutic targets. Future research directions involve elucidating context-specific Wnt signaling dynamics and exploring combination therapies to improve clinical outcomes for OSCC patients.

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