JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

New character of cancer immunotherapy: trends in viral tumor immunotherapy with influenza virus-based approaches

Author(s): Shiyao HU, Yiqi CAI, Yong SHEN, Yingkuan SHAO, Yushen DU, Yiding CHEN
Affiliation(s): Department of Breast Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; more
Corresponding email(s): ydchen@zju.edu.cn, lilyduyushen@zju.edu.cn
Key Words: Oncolytic virus; Influenza A virus; Antitumor; Reverse genetic technology; Vaccine; Viral immunotherapy

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Shiyao HU, Yiqi CAI, Yong SHEN, Yingkuan SHAO, Yushen DU, Yiding CHEN. New character of cancer immunotherapy: trends in viral tumor immunotherapy with influenza virus-based approaches[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2400381

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author="Shiyao HU, Yiqi CAI, Yong SHEN, Yingkuan SHAO, Yushen DU, Yiding CHEN",
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year="in press",
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doi="https://doi.org/10.1631/jzus.B2400381"
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%A Yingkuan SHAO
%A Yushen DU
%A Yiding CHEN
%J Journal of Zhejiang University SCIENCE B
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A1 - Yushen DU
A1 - Yiding CHEN
J0 - Journal of Zhejiang University Science B
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doi="https://doi.org/10.1631/jzus.B2400381"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Immunomodulatory cancer therapy is witnessing the rise of viral immunotherapy. The oncolytic influenza A virus, although promising in preclinical investigations, still remains to be implemented in clinical practice. Recent progress in genetic engineering, coupled with experiential insights, offers opportunities to enhance the therapeutic efficacy of the influenza A virus. This review explores the use of the influenza virus, its attenuated forms, and associated vaccines in cancer immunotherapy, highlighting their respective advantages and challenges. We further elucidate methods for engineering influenza viruses and innovative approaches to augment them with cytokines or immune checkpoint inhibitors, aiming to maximize their clinical impact. Our goal is to provide insights essential for refining influenza A virus-based viral tumor immunotherapies.

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