Abstract: The population of campus network users is diverse and complex, which increases the risk of computer virus infection when the terminal side of the campus network interacts with information. Therefore, it is crucial to explore how computer viruses propagate between terminals in the campus network. In this study, a novel computer virus-spreading model based on the characteristics of the basic network structure and a classical epidemic-spreading dynamics model, combined with actual university situations, is established. The proposed model contains six groups: susceptible group, unisolated latent group, isolated latent group, infection group, recovery group, and crash group. The proposed modelâĂŹs basic reproduction number and disease-free equilibrium point are analyzed. According to real university terminal computer virus propagation data, a basic computer virus infection rate, basic computer virus killing rate, and security protection strategy deployment rate are proposed to define the conversion probability of each group and perceive each groupâĂŹs variation tendency. Furthermore, we analyzed the spreading trend of computer viruses in the campus network in terms of the proposed computer virus spreading model. Specific measures are proposed to suppress the spread of computer viruses in terminals, to ensure the safe and stable operation of the campus network terminals to the greatest extent.