Full Text:  <905>

Suppl. Mater.: 

Summary:  <186>

CLC number: 

On-line Access: 2023-11-13

Received: 2022-08-19

Revision Accepted: 2022-11-02

Crosschecked: 2023-11-14

Cited: 0

Clicked: 1135

Citations:  Bibtex RefMan EndNote GB/T7714


Mustafa K. A. MOHAMMED


-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE A

Accepted manuscript available online (unedited version)

Biomaterial types, properties, medical applications, and other factors: a recent review

Author(s):  Reeya AGRAWAL, Anjan KUMAR, Mustafa K. A. MOHAMMED, Sangeeta SINGH

Affiliation(s):  VLSI Research Centre, GLA University, 281406 Mathura, India; more

Corresponding email(s):  mustafa_kareem97@yahoo.com

Key Words:  Surface severe plastic deformation (SSPD); Hyaluronan (HA); Extracellular matrix (ECM); Polyvinylchloride (PVC); Tissue engineering (TE)

Share this article to: More <<< Previous Paper|

Reeya AGRAWAL, Anjan KUMAR, Mustafa K. A. MOHAMMED, Sangeeta SINGH. Biomaterial types, properties, medical applications, and other factors: a recent review[J]. Journal of Zhejiang University Science A,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.A2200403

@article{title="Biomaterial types, properties, medical applications, and other factors: a recent review",
author="Reeya AGRAWAL, Anjan KUMAR, Mustafa K. A. MOHAMMED, Sangeeta SINGH",
journal="Journal of Zhejiang University Science A",
year="in press",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Biomaterial types, properties, medical applications, and other factors: a recent review
%A Anjan KUMAR
%A Mustafa K. A. MOHAMMED
%A Sangeeta SINGH
%J Journal of Zhejiang University SCIENCE A
%P 1027-1042
%@ 1673-565X
%D in press
%I Zhejiang University Press & Springer

T1 - Biomaterial types, properties, medical applications, and other factors: a recent review
A1 - Reeya AGRAWAL
A1 - Anjan KUMAR
A1 - Mustafa K. A. MOHAMMED
A1 - Sangeeta SINGH
J0 - Journal of Zhejiang University Science A
SP - 1027
EP - 1042
%@ 1673-565X
Y1 - in press
PB - Zhejiang University Press & Springer
ER -

Biomaterial research has been going on for several years, and many companies are heavily investing in new product development. However, it is a contentious field of science. Biomaterial science is a field that combines materials science and medicine. The replacement or restoration of damaged tissues or organs enhances the patient’s quality of life. The deciding aspect is whether or not the body will accept a biomaterial. A biomaterial used for an implant must possess certain qualities to survive a long time. When a biomaterial is used for an implant, it must have specific properties to be long-lasting. A variety of materials are used in biomedical applications. They are widely used today and can be used individually or in combination. This review will aid researchers in the selection and assessment of biomaterials. Before using a biomaterial, its mechanical and physical properties should be considered. Recent biomaterials have a structure that closely resembles that of tissue. Anti-infective biomaterials and surfaces are being developed using advanced antifouling, bactericidal, and antibiofilm technologies. This review tries to cover critical features of biomaterials needed for tissue engineering, such as bioactivity, self-assembly, structural hierarchy, applications, heart valves, skin repair, bio-design, essential ideas in biomaterials, bioactive biomaterials, bioresorbable biomaterials, biomaterials in medical practice, biomedical function for design, biomaterial properties such as biocompatibility, heat response, non-toxicity, mechanical properties, physical properties, wear, and corrosion, as well as biomaterial properties such surfaces that are antibacterial, nanostructured materials, and biofilm disrupting compounds, are all being investigated. It is technically possible to stop the spread of implant infection.


作者:Reeya AGRAWAL1,3, Anjan KUMAR1, Mustafa K. A. MOHAMMED2, Sangeeta SINGH3
机构:1VLSI Research Centre, GLA University, 281406 Mathura, India;2Radiological Techniques Department, Al-Mustaqbal University College, 51001 Hillah, Babylon, Iraq;3Microelectronics & VLSI Lab, National Institute of Technology, Patna 800005, India


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]AbreuH, CancianiE, RaineriD, et al., 2022. Extracellular vesicles in musculoskeletal regeneration: modulating the therapy of the future. Cells, 11(1):43.

[2]Ackun-FarmmerMA, OverbyCT, HawsBE, et al., 2021. Biomaterials for orthopedic diagnostics and theranostics. Current Opinion in Biomedical Engineering, 19:100308.

[3]AdorinniS, CringoliMC, PerathonerS, et al., 2021. Green approaches to carbon nanostructure-based biomaterials. Applied Sciences, 11(6):2490.

[4]AhmedDS, MohammedMKA, 2020. Studying the bactericidal ability and biocompatibility of gold and gold oxide nanoparticles decorating on multi-wall carbon nanotubes. Chemical Papers, 74(11):4033-4046.

[5]AhmedDS, MohammedMKA, MohammadMR, 2020. Sol‍–gel synthesis of Ag-doped titania-coated carbon nanotubes and study their biomedical applications. Chemical Papers, 74(1):197-208.

[6]Al RugaieO, JabirMS, MohammedMKA, et al., 2022. Modification of SWCNTs with hybrid materials ZnO‍–Ag and ZnO‍–‍Au for enhancing bactericidal activity of phagocytic cells against Escherichia coli through NOX2 pathway. Scientific Reports, 12(1):17203.

[7]AlhujailyM, AlbukhatyS, YusufM, et al., 2022. Recent advances in plant-mediated zinc oxide nanoparticles with their significant biomedical properties. Bioengineering, 9(10):541.

[8]AlshemaryAZ, HussainR, DalgicAD, et al., 2022a. Bactericidal and in vitro osteogenic activity of nano sized cobalt-doped silicate hydroxyapatite. Ceramics International, 48(19):28231-28239.

[9]AlshemaryAZ, MotameniA, EvisZ, 2022b. Biomedical applications of metal oxide‍–‍carbon composites. In: Chaudhry MA, Hussain R, Butt FK (Eds.), Metal Oxide-Carbon Hybrid Materials. Elsevier, Amsterdam, the Netherlands, p.371-405.

[10]AlshemaryAZ, MuhammedY, SalmanNA, et al., 2022c. In vitro degradation and bioactivity of antibacterial chromium doped β‍-tricalcium phosphate bioceramics. Ceramics‍–Silikáty, 66(3):347-353.

[11]ArifMM, KhanSM, GullN, et al., 2021. Polymer-based biomaterials for chronic wound management: promises and challenges. International Journal of Pharmaceutics, 598:120270.

[12]ArifZU, KhalidMY, ZolfagharianA, et al., 2022. 4D bioprinting of smart polymers for biomedical applications: recent progress, challenges, and future perspectives. Reactive and Functional Polymers, 179:105374.

[13]BastolaAK, PaudelM, LiL, et al., 2020. Recent progress of magnetorheological elastomers: a review. Smart Materials and Structures, 29(12):123002.

[14]BelloAB, KimD, KimD, et al., 2020. Engineering and functionalization of gelatin biomaterials: from cell culture to medical applications. Tissue Engineering Part B: Reviews, 26(2):164-180.

[15]BhattacharyyaA, JanarthananG, NohI, 2021. Nano-biomaterials for designing functional bioinks towards complex tissue and organ regeneration in 3D bioprinting. Additive Manufacturing, 37:101639.

[16]BonferoniMC, CaramellaC, CatenacciL, et al., 2021. Biomaterials for soft tissue repair and regeneration: a focus on Italian research in the field. Pharmaceutics, 13(9):1341.

[17]CastroD, JaegerP, BaptistaAC, et al., 2021. An overview of high-entropy alloys as biomaterials. Metals, 11(4):648.

[18]ChaoWX, LiYD, SunXH, et al., 2021. Enhanced wood-derived photothermal evaporation system by in-situ incorporated lignin carbon quantum dots. Chemical Engineering Journal, 405:126703.

[19]ChenL, ChengLY, WangZ, et al., 2021. Conditioned medium-electrospun fiber biomaterials for skin regeneration. Bioactive Materials, 6(2):361-374.

[20]ChuS, WangAL, BhattacharyaA, et al., 2021. Protein based biomaterials for therapeutic and diagnostic applications. Progress in Biomedical Engineering, 4(1):012003.

[21]CristTE, MathewPJ, PlotskerEL, et al., 2021. Biomaterials in craniomaxillofacial reconstruction: past, present, and future. Journal of Craniofacial Surgery, 32(2):535-540.

[22]DargahiA, SedaghatiR, RakhejaS, 2019. On the properties of magnetorheological elastomers in shear mode: design, fabrication and characterization. Composites Part B: Engineering, 159:269-283.

[23]do NascimentoMHM, FerreiraM, MalmongeSM, et al., 2017. Evaluation of cell interaction with polymeric biomaterials based on hyaluronic acid and chitosan. Journal of Materials Science: Materials in Medicine, 28(5):68.

[24]DziadekM, DziadekK, ChecinskaK, et al., 2021. PCL and PCL/bioactive glass biomaterials as carriers for biologically active polyphenolic compounds: comprehensive physicochemical and biological evaluation. Bioactive Materials, 6(6):1811-1826.

[25]GonzálezOM, GarcíaA, GuachambalaM, et al., 2021. Innovative sandwich-like composite biopanels‍–‍towards a new building biomaterials concept for structural applications in nonconventional building systems. Wood Material Science & Engineering, 16(2):132-148.

[26]GovindanN, MohammedMKA, TamilarasuS, 2022. Nano-sized plant particles for next generation green-medicine. Materials Letters, 309:131301.

[27]HasanF, Al MahmudKAH, KhanMI, et al., 2021. Cavitation induced damage in soft biomaterials. Multiscale Science and Engineering, 3(1):67-87.

[28]HayajnehM, Al-OqlaFM, 2022. Physical and mechanical inherent characteristic investigations of various Jordanian natural fiber species to reveal their potential for green biomaterials. Journal of Natural Fibers, 19(13):7199-7212.

[29]HolmesDW, SinghD, LamontR, et al., 2022. Mechanical behaviour of flexible 3D printed gyroid structures as a tuneable replacement for soft padding foam. Additive Manufacturing, 50:102555.

[30]HussainS, LiSX, MumtazM, et al., 2021. Foliar application of silicon improves stem strength under low light stress by regulating lignin biosynthesis genes in soybean (Glycine max (L.) Merr.). Journal of Hazardous Materials, 401:123256.

[31]IndurkarA, PanditA, JainR, et al., 2021. Plant-based biomaterials in tissue engineering. Bioprinting, 21:e00127.

[32]JablonskáE, KubásekJ, VojtěchD, et al., 2021. Test conditions can significantly affect the results of in vitro cytotoxicity testing of degradable metallic biomaterials. Scientific Reports, 11(1):6628.

[33]JanarthananG, NohI, 2021. Recent trends in metal ion based hydrogel biomaterials for tissue engineering and other biomedical applications. Journal of Materials Science & Technology, 63:35-53.

[34]JasimSA, OpulenciaMJC, Ramírez-CoronelAA, et al., 2022. The emerging role of microbiota-derived short-chain fatty acids in immunometabolism. International Immunopharmacology, 110:108983.

[35]JinM, ShiJL, ZhuWZ, et al., 2021. Polysaccharide-based biomaterials in tissue engineering: a review. Tissue Engineering Part B: Reviews, 27(6):604-626.

[36]JinS, XiaX, HuangJH, et al., 2021. Recent advances in PLGA-based biomaterials for bone tissue regeneration. Acta Biomaterialia, 127:56-79.

[37]KalirajanC, DukleA, NathanaelAJ, et al., 2021. A critical review on polymeric biomaterials for biomedical applications. Polymers, 13(17):3015.

[38]KhalidMY, Al RashidA, ArifZU, et al., 2021. Recent advances in nanocellulose-based different biomaterials: types, properties, and emerging applications. Journal of Materials Research and Technology, 14:2601-2623.

[39]KsiążekM, 2021. Retracted: application of sulfur waste in biomaterials. Composites Part B: Engineering, 217:108848.

[40]KumarA, ColliniL, UrsiniC, et al., 2022. Energy absorption and stiffness of thin and thick-walled closed-cell 3D-printed structures fabricated from a hyperelastic soft polymer. Materials, 15(7):2441.

[41]KumariS, ChatterjeeK, 2021. Biomaterials-based formulations and surfaces to combat viral infectious diseases. APL Bioengineering, 5(1):011503.

[42]LiYX, WangSS, JinLZ, et al., 2018. Self-assembly rules of dumbbell-shaped molecules and their effect on morphology and photophysical behaviors of micro/nanocrystals. Crystal Growth & Design, 18(9):4822-4828.

[43]LiuYY, JiangHM, ZhangLT, et al., 2022. Diluted acetic acid softened intermuscular bones from silver carp (Hypophthalmichthys molitrix) by dissolving hydroxyapatite and collagen. Foods, 11(1):1.

[44]LiuZQ, LiuXL, RamakrishnaS, 2021. Surface engineering of biomaterials in orthopedic and dental implants: strategies to improve osteointegration, bacteriostatic and bactericidal activities. Biotechnology Journal, 16(7):2000116.

[45]MaCL, NikiforovA, de GeyterN, et al., 2022. Plasma for biomedical decontamination: from plasma-engineered to plasma-active antimicrobial surfaces. Current Opinion in Chemical Engineering, 36:100764.

[46]MaYM, GaoL, TianYQ, et al., 2021. Advanced biomaterials in cell preservation: hypothermic preservation and cryopreservation. Acta Biomaterialia, 131:97-116.

[47]MahmoodRI, KadhimAA, IbraheemS, et al., 2022. Biosynthesis of copper oxide nanoparticles mediated Annona muricata as cytotoxic and apoptosis inducer factor in breast cancer cell lines. Scientific Reports, 12(1):16165.

[48]MohammedMKA, AhmedDS, MohammadMR, 2019. Studying antimicrobial activity of carbon nanotubes decorated with metal-doped ZnO hybrid materials. Materials Research Express, 6(5):055404.

[49]MohammedMKA, MohammadMR, JabirMS, et al., 2020. Functionalization, characterization, and antibacterial activity of single wall and multi wall carbon nanotubes. IOP Conference Series: Materials Science and Engineering, 757:012028.

[50]MominM, MishraV, GharatS, et al., 2021. Recent advancements in cellulose-based biomaterials for management of infected wounds. Expert Opinion on Drug Delivery, 18(11):1741-1760.

[51]MondalD, GriffithM, VenkatramanSS, 2016. Polycaprolactone-based biomaterials for tissue engineering and drug delivery: current scenario and challenges. International Journal of Polymeric Materials and Polymeric Biomaterials, 65(5):255-265.

[52]MorenoMA, Gonzalez-RicoJ, Lopez-DonaireML, et al., 2021. New experimental insights into magneto-mechanical rate dependences of magnetorheological elastomers. Composites Part B: Engineering, 224:109148.

[53]MoritaJ, AndoY, KomatsuS, et al., 2021. Mechanical properties and reliability of parametrically designed architected materials using urethane elastomers. Polymers, 13(5):842.

[54]MotameniA, AlshemaryAZ, EvisZ, 2021. A review of synthesis methods, properties and use of monetite cements as filler for bone defects. Ceramics International, 47(10):13245-13256.

[55]MusiołM, SikorskaW, JaneczekH, et al., 2018. (Bio)degradable polymeric materials for a sustainable future–part 1. Organic recycling of PLA/PBAT blends in the form of prototype packages with long shelf-life. Waste Management, 77:447-454.

[56]NaceSE, TiernanJ, HollandD, et al., 2021. A comparative analysis of the compression characteristics of a thermoplastic polyurethane 3D printed in four infill patterns for comfort applications. Rapid Prototyping Journal, 27(11):24-36.

[57]NickkholghB, HickersonDHM, WilkinsC, et al., 2022. Regenerative medicine: the newest cellular therapy. In: Gee AP (Ed.), Cell Therapy. Springer, Cham, Germany, p.517-537.

[58]NooriAS, MageedNF, AbdalameerNK, et al., 2022. The histological effect of activated Aloe Vera extract by microwave plasma on wound healing. Chemical Physics Letters, 807:140112.

[59]NouriA, ShirvanAR, LiYC, et al., 2021. Additive manufacturing of metallic and polymeric load-bearing biomaterials using laser powder bed fusion: a review. Journal of Materials Science & Technology, 94:196-215.

[60]ParkKM, MinKS, RohYS, 2022. Design optimization of lattice structures under compression: study of unit cell types and cell arrangements. Materials, 15(1):97.

[61]ParkSY, YunYH, ParkBJ, et al., 2022. Fabrication and biological activities of plasmid DNA gene carrier nanoparticles based on biodegradable L‍-tyrosine polyurethane. Pharmaceuticals, 15(1):17.

[62]QinLD, YaoS, ZhaoJX, et al., 2021. Review on development and dental applications of polyetheretherketone-based biomaterials and restorations. Materials, 14(2):408.

[63]RahmatiM, SilvaEA, ReselandJE, et al., 2020. Biological responses to physicochemical properties of biomaterial surface. Chemical Society Reviews, 49(15):5178-5224.

[64]RashidT, SherF, KhanAS, et al., 2021. Effect of protic ionic liquid treatment on the pyrolysis products of lignin extracted from oil palm biomass. Fuel, 291:120133.

[65]RoachDJ, RohskopfA, HamelCM, et al., 2021. Utilizing computer vision and artificial intelligence algorithms to predict and design the mechanical compression response of direct ink write 3D printed foam replacement structures. Additive Manufacturing, 41:101950.

[66]SaadatmandM, Al-AwsiGRL, AlanaziAD, et al., 2021. Green synthesis of zinc nanoparticles using Lavandula angustifolia Vera. Extract by microwave method and its prophylactic effects on Toxoplasma gondii infection. Saudi Journal of Biological Sciences, 28(11):6454-6460.

[67]SadowskaJM, GenoudKJ, KellyDJ, et al., 2021. Bone biomaterials for overcoming antimicrobial resistance: advances in non-antibiotic antimicrobial approaches for regeneration of infected osseous tissue. Materials Today, 46:136-154.

[68]SalihuR, AbdRazak SI, ZawawiNA, et al., 2021. Citric acid: a green cross-linker of biomaterials for biomedical applications. European Polymer Journal, 146:110271.

[69]SaydéT, El HamouiO, AliesB, et al., 2021. Biomaterials for three-dimensional cell culture: from applications in oncology to nanotechnology. Nanomaterials, 11(2):481.

[70]SivasankarapillaiVS, DasSS, SabirF, et al., 2021. Progress in natural polymer engineered biomaterials for transdermal drug delivery systems. Materials Today Chemistry, 19:100382.

[71]SuvindranN, ServatiA, ServatiP, 2022. Emerging biomedical and industrial applications of nanoporous materials. In: Uthaman A, Thomas S, Li TD (Eds.), Advanced Functional Porous Materials. Springer, Cham, Germany, p.353-390.

[72]SzczukaJ, SandomierskiM, BuchwaldT, 2022. Formation of the octadecylphosphonic acid layer on the surface of Ti6Al4V ELI titanium alloy and analysis using Raman spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 265:120368.

[73]TaoYB, LiP, ZhangHW, et al., 2022. Compression and flexural properties of rigid polyurethane foam composites reinforced with 3D-printed polylactic acid lattice structures. Composite Structures, 279:114866.

[74]ThrivikramanG, MadrasG, BasuB, 2014. In vitro/in vivo assessment and mechanisms of toxicity of bioceramic materials and its wear particulates. RSC Advances, 4(25):12763-12781.

[75]VakilMK, MansooriY, Al-AwsiGRL, et al., 2022. Individual genetic variability mainly of proinflammatory cytokines, cytokine receptors, and toll-like receptors dictates pathophysiology of COVID-19 disease. Journal of Medical Virology, 94(9):4088-4096.

[76]WanMC, QinW, LeiC, et al., 2021. Biomaterials from the sea: future building blocks for biomedical applications. Bioactive Materials, 6(12):4255-4285.

[77]WangF, GuoCC, YangQQ, et al., 2021. Protein composites from silkworm cocoons as versatile biomaterials. Acta Biomaterialia, 121:180-192.

[78]WangY, HuangY, BaiHY, et al., 2021. Biocompatible and biodegradable polymer optical fiber for biomedical application: a review. Biosensors, 11(12):472.

[79]WangYM, LiuP, ZhangGF, et al., 2021. Cascading of engineered bioenergy plants and fungi sustainable for low-cost bioethanol and high-value biomaterials under green-like biomass processing. Renewable and Sustainable Energy Reviews, 137:110586.

[80]WilfredO, TaiHY, MarriottR, et al., 2018. Biodegradation of polyactic acid and starch composites in compost and soil. International Journal of Nano Research, 1(2):1-11.

[81]WuS, HuWQ, ZeQJ, et al., 2020. Multifunctional magnetic soft composites: a review. Multifunctional Materials, 3(4):042003.

[82]XiangY, JinRR, ZhangY, et al., 2021. Foldable glistening-free acrylic intraocular lens biomaterials with dual-side heterogeneous surface modification for postoperative endophthalmitis and posterior capsule opacification prophylaxis. Biomacromolecules, 22(8):3510-3521.

[83]XuC, WangDY, ZhangSW, et al., 2021. Effect of lignin modifier on engineering performance of bituminous binder and mixture. Polymers, 13(7):1083.

[84]YeungDA, KellyNH, 2021. The role of collagen-based biomaterials in chronic wound healing and sports medicine applications. Bioengineering, 8(1):8.

[85]YilmazB, AlshemaryAZ, EvisZ, 2019. Co-doped hydroxyapatites as potential materials for biomedical applications. Microchemical Journal, 144:443-453.

[86]YuW, MaynardE, ChiaradiaV, et al., 2021. Aliphatic polycarbonates from cyclic carbonate monomers and their application as biomaterials. Chemical Reviews, 121(18):10865-10907.

[87]ZhangL, QuY, GuJ, et al., 2021. Photoswitchable solvent-free DNA thermotropic liquid crystals toward self-erasable shape information recording biomaterials. Materials Today Bio, 12:100140.

[88]ZhaoK, YangX, ChenGQ, et al., 2002. Effect of lipase treatment on the biocompatibility of microbial polyhydroxyalkanoates. Journal of Materials Science: Materials in Medicine, 13(9):849-854.

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE