JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE A

Accepted manuscript available online (unedited version)

The preparation and properties of polyethylene glycol-b-poly (acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches

Author(s): Yichuan HONG, Haojie YU, Li WANG, Xiang CHEN, Di SHEN, Yu WANG, Shuning REN, Yudi HUANG, Jian YANG
Affiliation(s): State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; more
Corresponding email(s): hjyu@zju.edu.cn
Key Words: Diabetes; Hyaluronic acid; Phenylboronic acid; Glucose responsive hydrogel; Microneedles

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Yichuan HONG, Haojie YU, Li WANG, Xiang CHEN, Di SHEN, Yu WANG, Shuning REN, Yudi HUANG, Jian YANG. The preparation and properties of polyethylene glycol-b-poly (acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches[J]. Journal of Zhejiang University Science A,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.A2300386

@article{title="The preparation and properties of polyethylene glycol-b-poly (acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches",
author="Yichuan HONG, Haojie YU, Li WANG, Xiang CHEN, Di SHEN, Yu WANG, Shuning REN, Yudi HUANG, Jian YANG",
journal="Journal of Zhejiang University Science A",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.A2300386"
}

%0 Journal Article
%T The preparation and properties of polyethylene glycol-b-poly (acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches
%A Yichuan HONG
%A Haojie YU
%A Li WANG
%A Xiang CHEN
%A Di SHEN
%A Yu WANG
%A Shuning REN
%A Yudi HUANG
%A Jian YANG
%J Journal of Zhejiang University SCIENCE A
%P
%@ 1673-565X
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.A2300386"

TY - JOUR
T1 - The preparation and properties of polyethylene glycol-b-poly (acrylamidophenylboronic acid) glucose responsive particles and their hyaluronic acid-based microneedle patches
A1 - Yichuan HONG
A1 - Haojie YU
A1 - Li WANG
A1 - Xiang CHEN
A1 - Di SHEN
A1 - Yu WANG
A1 - Shuning REN
A1 - Yudi HUANG
A1 - Jian YANG
J0 - Journal of Zhejiang University Science A
SP -
EP -
%@ 1673-565X
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.A2300386"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: To overcome the pain and risk of hypoglycemia in insulin administration, glucose-responsive microneedles have been developed by researchers, which could release insulin according to the blood glucose level. We designed a kind of particles by a RAFT method containing a phenylboronic acid group as the sensor of glucose and carrier of insulin. Polyethylene glycol (PEG)-DDMAT was synthesized as a macromolecular RAFT agent, which was then reacted with 3-acrylamidophenylboronic acid (AAPBA) to synthesize the block copolymer PEG-b-PAAPBA. Glucose-responsive particles loaded with insulin were prepared by self-assembly based on hydrophilic-hydrophobic interactions. Microneedle patches loaded with glucose-responsive particles were prepared using hyaluronic acid as the substrate. The insulin release behavior of the particles in glucose solutions of 0, 100, and 400 mg/dL showed significant glucose responsiveness and good biosafety. The results of blood glucose control experiments in rats indicate that a single microneedle patch can effectively maintain normal blood glucose for over 7 hours.

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