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On-line Access: 2022-02-17

Received: 2021-04-25

Revision Accepted: 2021-08-30

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Yin LI




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Journal of Zhejiang University SCIENCE B

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Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1

Author(s):  Chenxi GAO, Jinming SHI, Jingxin ZHANG, Yin LI, Yi ZHANG

Affiliation(s):  Department of Gynecology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China; more

Corresponding email(s):  syzi@163.com, yinli@bjmu.edu.cn

Key Words:  Ovarian cancer; Intraperitoneal tumor microenvironment; Chemerin; Programmed death ligand 1 (PD-L1)

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Chenxi GAO, Jinming SHI, Jingxin ZHANG, Yin LI, Yi ZHANG. Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1[J]. Journal of Zhejiang University Science B, 2022, 23(7): 164-170.

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publisher="Zhejiang University Press & Springer",

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Ovarian cancer is the third-most-common malignant reproductive tumor in women. According to the American Cancer Society, it has the highest mortality rate of gynecological tumors. The five-year survival rate was only 29% during the period from 1975 to 2008 (Reid et al., 2017). In recent decades, the five-year survival rate of ovarian cancer has remained around 30% despite continuous improvements in surgery, chemotherapy, radiotherapy, and other therapeutic methods. However, because of the particularity of the volume and location of ovarian tissue, the early symptoms of ovarian cancer are hidden, and there is a lack of highly sensitive and specific screening methods. Most patients have advanced metastasis, including abdominal metastasis, when they are diagnosed (Reid et al., 2017). Therefore, exploring the mechanism of ovarian cancer metastasis and finding early preventive measures are key to improving the survival rate and reducing mortality caused by ovarian cancer.




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