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Journal of Zhejiang University SCIENCE B

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Molecular hydrogen is a promising therapeutic agent for pulmonary disease

Author(s):  Zhiling FU, Jin ZHANG

Affiliation(s):  Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

Corresponding email(s):  zhangjin11170@163.com

Key Words:  Molecular hydrogen; Pulmonary disease; Reactive oxygen species (ROS); Oxidative stress; Inflammation

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Zhiling FU, Jin ZHANG. Molecular hydrogen is a promising therapeutic agent for pulmonary disease[J]. Journal of Zhejiang University Science B, 2022, 23(2): 102-122.

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A1 - Zhiling FU
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Molecular hydrogen exerts biological effects on nearly all organs. It has anti-oxidative, anti-inflammatory, and anti-aging effects and contributes to the regulation of autophagy and cell death. As the primary organ for gas exchange, the lungs are constantly exposed to various harmful environmental irritants. Short- or long-term exposure to these harmful substances often results in lung injury, causing respiratory and lung diseases. Acute and chronic respiratory diseases have high rates of morbidity and mortality and have become a major public health concern worldwide. For example, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic. An increasing number of studies have revealed that hydrogen may protect the lungs from diverse diseases, including acute lung injury, chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary arterial hypertension, and pulmonary fibrosis. In this review, we highlight the multiple functions of hydrogen and the mechanisms underlying its protective effects in various lung diseases, with a focus on its roles in disease pathogenesis and clinical significance.




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