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Journal of Zhejiang University SCIENCE B

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Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway


Author(s):  Yuzhu XU, Pan FAN, Lei LIU, Xuanfei XU, Lele ZHANG, Jiadong WANG, Yu’ao TAO, Xiaolong LI, Xi LI, Yuntao WANG

Affiliation(s):  Medical School of Southeast University, Southeast University, Nanjing 210009, China; more

Corresponding email(s):  wangyttodd@163.com

Key Words:  Mesenchymal stem cells; Ferroptosis; Oxidative stress; Iron metabolism; Lipid peroxidation; Glutathione peroxidase 4


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Yuzhu XU, Pan FAN, Lei LIU, Xuanfei XU, Lele ZHANG, Jiadong WANG, Yu’ao TAO, Xiaolong LI, Xi LI, Yuntao WANG. Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway[J]. Journal of Zhejiang University Science B, 1998, -1(7): .

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author="Yuzhu XU, Pan FAN, Lei LIU, Xuanfei XU, Lele ZHANG, Jiadong WANG, Yu’ao TAO, Xiaolong LI, Xi LI, Yuntao WANG",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200410"
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%A Yuzhu XU
%A Pan FAN
%A Lei LIU
%A Xuanfei XU
%A Lele ZHANG
%A Jiadong WANG
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%A Xiaolong LI
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%A Yuntao WANG
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%@ 1673-1581
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A1 - Yuzhu XU
A1 - Pan FAN
A1 - Lei LIU
A1 - Xuanfei XU
A1 - Lele ZHANG
A1 - Jiadong WANG
A1 - Yu’
A1 - ao TAO
A1 - Xiaolong LI
A1 - Xi LI
A1 - Yuntao WANG
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Abstract: 
Ex vivo culture-amplified mesenchymal stem cells (MSCs) have been studied because of their capacity for healing tissue injury. MSC transplantation is a valid approach for promoting the repair of damaged tissues and replacement of lost cells or to safeguard surviving cells. But currently the efficiency of MSC transplantation is constrained by the extensive loss of MSCs during the short post-transplantation period. Hence, strategies to increase the efficacy of MSC treatment are urgently needed. Iron overload, reactive oxygen species deposition and decreased antioxidant capacity suppress the proliferation and regeneration of MSCs, thereby hastening cell death. Notably, oxidative stress and deficient antioxidant defence induced by iron overload can result in ferroptosis. Ferroptosis may inhibit cell survival after MSC transplantation, thereby reducing clinical efficacy. In this review, we explore the role of ferroptosis in MSC performance. Given that little research has focused on ferroptosis in transplanted MSCs, further study is urgently needed to enhance the in vivo implantation, function, and duration of MSCs.

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