Affiliation(s):
Medical School of Southeast University, Southeast University, Nanjing 210009, China;
moreAffiliation(s): Medical School of Southeast University, Southeast University, Nanjing 210009, China; Department of Spine Surgery, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, China; Department of Nuclear Medicine, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, China;
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Yuzhu XU, Pan FAN, Lei LIU, Xuanfei XU, Lele ZHANG, Jiadong WANG, Yu’ao TAO, Xiaolong LI, Xi LI, Yuntao WANG. Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway[J]. Journal of Zhejiang University Science B, 1998, -1(7): .
@article{title="Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway", author="Yuzhu XU, Pan FAN, Lei LIU, Xuanfei XU, Lele ZHANG, Jiadong WANG, Yu’ao TAO, Xiaolong LI, Xi LI, Yuntao WANG", journal="Journal of Zhejiang University Science B", volume="-1", number="-1", pages="", year="1998", publisher="Zhejiang University Press & Springer", doi="10.1631/jzus.B2200410" }
%0 Journal Article %T Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway %A Yuzhu XU %A Pan FAN %A Lei LIU %A Xuanfei XU %A Lele ZHANG %A Jiadong WANG %A Yu’ %A ao TAO %A Xiaolong LI %A Xi LI %A Yuntao WANG %J Journal of Zhejiang University SCIENCE B %V -1 %N -1 %P %@ 1673-1581 %D 1998 %I Zhejiang University Press & Springer
TY - JOUR T1 - Novel perspective in transplantation therapy of mesenchymal stem cells: targeting the ferroptosis pathway A1 - Yuzhu XU A1 - Pan FAN A1 - Lei LIU A1 - Xuanfei XU A1 - Lele ZHANG A1 - Jiadong WANG A1 - Yu’ A1 - ao TAO A1 - Xiaolong LI A1 - Xi LI A1 - Yuntao WANG J0 - Journal of Zhejiang University Science B VL - -1 IS - -1 SP - EP - %@ 1673-1581 Y1 - 1998 PB - Zhejiang University Press & Springer ER -
Abstract: Ex vivo culture-amplified mesenchymal stem cells (MSCs) have been studied because of their capacity for healing tissue injury. MSC transplantation is a valid approach for promoting the repair of damaged tissues and replacement of lost cells or to safeguard surviving cells. But currently the efficiency of MSC transplantation is constrained by the extensive loss of MSCs during the short post-transplantation period. Hence, strategies to increase the efficacy of MSC treatment are urgently needed. Iron overload, reactive oxygen species deposition and decreased antioxidant capacity suppress the proliferation and regeneration of MSCs, thereby hastening cell death. Notably, oxidative stress and deficient antioxidant defence induced by iron overload can result in ferroptosis. Ferroptosis may inhibit cell survival after MSC transplantation, thereby reducing clinical efficacy. In this review, we explore the role of ferroptosis in MSC performance. Given that little research has focused on ferroptosis in transplanted MSCs, further study is urgently needed to enhance the in vivo implantation, function, and duration of MSCs.
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