JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Incidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma

Author(s): Lijuan XU, Xinyao ZHANG, Yang CAO, Yin ZHAO, Juan GU, Wenqing YE, Xiaojie WANG, Jinxin LI, Ruiyi REN, Yuanbo LIANG
Affiliation(s): National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China; more
Corresponding email(s): yuanboliang@wmu.edu.cn, renruiyi@bu.edu
Key Words: Early transient intraocular pressure elevation; Canaloplasty; Primary open-angle glaucoma; Risk factor

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Lijuan XU, Xinyao ZHANG, Yang CAO, Yin ZHAO, Juan GU, Wenqing YE, Xiaojie WANG, Jinxin LI, Ruiyi REN, Yuanbo LIANG. Incidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2200485

@article{title="Incidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma",
author="Lijuan XU, Xinyao ZHANG, Yang CAO, Yin ZHAO, Juan GU, Wenqing YE, Xiaojie WANG, Jinxin LI, Ruiyi REN, Yuanbo LIANG",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2200485"
}

%0 Journal Article
%T Incidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma
%A Lijuan XU
%A Xinyao ZHANG
%A Yang CAO
%A Yin ZHAO
%A Juan GU
%A Wenqing YE
%A Xiaojie WANG
%A Jinxin LI
%A Ruiyi REN
%A Yuanbo LIANG
%J Journal of Zhejiang University SCIENCE B
%P 366-370
%@ 1673-1581
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%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2200485"

TY - JOUR
T1 - Incidence and risk factors of early transient intraocular pressure elevation after canaloplasty for primary open-angle glaucoma
A1 - Lijuan XU
A1 - Xinyao ZHANG
A1 - Yang CAO
A1 - Yin ZHAO
A1 - Juan GU
A1 - Wenqing YE
A1 - Xiaojie WANG
A1 - Jinxin LI
A1 - Ruiyi REN
A1 - Yuanbo LIANG
J0 - Journal of Zhejiang University Science B
SP - 366
EP - 370
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
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doi="https://doi.org/10.1631/jzus.B2200485"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Glaucoma is one of the most common optic neuropathies, featuring progressive retinal ganglion cell damage and visual field loss (Tham et al., 2014; Xu et al., 2020). Currently, the only effective treatment for this condition is the reduction of intraocular pressure (IOP) (Palmberg, 2001; Heijl et al., 2002). Canaloplasty is a proven bleb-independent surgery with good efficacy and safety profiles in primary open-angle glaucoma (POAG) (Gołaszewska et al., 2021). However, early transient postoperative IOP elevation has been reported in up to 30% of cases (Riva et al., 2019), similar to that commonly observed in other internal drainage glaucoma surgeries such as implantation using iStent (0%–21.0%), CyPass (10.8%), and Hydrus (4.8%–6.5%) (Lavia et al., 2017). This complication may be a predictor of poor reserve in the outflow system and is potentially associated with surgical failure. Nonetheless, the exact pathophysiology of glaucoma remains unknown, and studies clarifying the risk factors for postoperative IOP elevation have been scarce.

原发性开角型青光眼黏小管成形术后早期短暂性高眼压的发生率及危险因素分析

徐丽娟^1,2,3，张欣瑶^1,2,3，曹阳^1,2,3，赵崟^1,2,3，古娟⁴，叶雯青^1,2,3，王小洁^1,2,3，李金鑫^1,2,3，任瑞漪^1,2,3，梁远波^1,2,3
¹温州医科大学附属眼视光医院，国家眼耳鼻喉疾病临床医学研究中心（眼部疾病），中国温州市，325027
²温州医科大学附属眼视光医院，省部共建国家眼视光学和视觉科学重点实验室，中国温州市，325027
³温州医科大学青光眼研究所，中国温州市，325027
⁴成都大学附属医院，中国成都市，610086
摘要：为分析原发性开角型青光眼（primary open-angle glaucoma，POAG）黏小管成形术后早期短暂性高眼压的发生率及危险因素，本研究纳入了本院顺利完成360°黏小管成形术的POAG患者。我们收集了以下数据：术后各随访时间点眼压（intraocular pressure，IOP），术后早期是否发生短暂性高眼压（定义：术后1周至3月内IOP>21 mmHg但能回落至≤21 mmHg）及术后一周最低IOP（IOP_min-1w）。根据是否发生术后早期短暂性高眼压，将其分为正常眼压组（normal IOP，NIOP）和短暂性高眼压组（high IOP，HIOP）。此外，我们也对术后早期短暂性高眼压的相关危险因素进行了分析。最终来自57位患者的57只眼纳入分析。他们的平均视野缺损值(mean defect, MD)为(-15.57±10.13) dB，IOP由术前 (29.43±10.27) mmHg显著降低至术后1年的(14.73±3.60) mmHg（P<0.01）。其中，20只眼发生HIOP（35.1%）。HIOP组的IOP_min-1w显著高于NIOP组（P<0.01），并与较低的1年完全成功率相关。本研究结果提示POAG中黏小管成形术后HIOP组患者可能IOP_min-1w较高，1年手术效果较差，且IOP_min-1w≥12 mmHg可能是HIOP发生的独立危险因素。

关键词组：早期短暂性高眼压；黏小管成形术；原发性开角型青光眼（POAG）；危险因素

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Reference

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原发性开角型青光眼黏小管成形术后早期短暂性高眼压的发生率及危险因素分析

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