CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2023-12-12
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Pengfei GAO, Wentao ZHANG, Yujie LIN, Ruijie LU, Zijian LOU, Gang LU, Ruolang PAN, Yunfang CHEN. Luteolin suppresses oral carcinoma 3 (OC3) cell growth and migration via modulating polo-like kinase 1 (PLK1) expression and cellular energy metabolism[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300200 @article{title="Luteolin suppresses oral carcinoma 3 (OC3) cell growth and migration via modulating polo-like kinase 1 (PLK1) expression and cellular energy metabolism", %0 Journal Article TY - JOUR
木犀草素通过调节PLK1表达和细胞能量代谢抑制口腔癌细胞OC3的生长和迁移1浙江省人民医院,杭州医学院附属人民医院口腔科整形重建外科中心,中国杭州市,310014 2蚌埠医学院口腔医学院,中国蚌埠市,233030 3温州医科大学附属第二临床医学院,中国温州市,325035 4浙江省细胞药物与应用技术研究重点实验室,中国杭州市,311122 摘要:尽管木犀草素的抗癌作用已在多种肿瘤模型中报道,但关于其在口腔癌中的作用研究鲜少。本研究探讨了木犀草素对口腔癌细胞OC3生长和迁移的影响及其机制。结果表明,木犀草素能够抑制或下调OC3细胞的增殖、细胞周期以及p53-Ser15(P)和polo样激酶1(PLK1)蛋白水平。耗氧率(OCR)和胞外酸化率(ECAR)水平以及ATP产量也显著降低。Transwell试验进一步证实OC3细胞的迁移能力会受到木犀草素的影响。综上,本研究发现木犀草素能抑制口腔癌细胞OC3的增殖,其机制可能与p53-PLK1信号传导下调和细胞能量代谢降低有关。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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