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On-line Access: 2023-12-21

Received: 2023-07-11

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Journal of Zhejiang University SCIENCE B

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Immune checkpoint blockade for cancer therapy: current progress and perspectives


Author(s):  Hongying YE, Weijie LIAO, Jiongli PAN, Yin SHI, Qingqing WANG

Affiliation(s):  Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China; more

Corresponding email(s):  wqq@zju.edu.cn, yinshi@zju.edu.cn

Key Words:  Immune checkpoint blockade; Cancer immunotherapy; Tumor immune evasion; Immune normalization


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Hongying YE, Weijie LIAO, Jiongli PAN, Yin SHI, Qingqing WANG. Immune checkpoint blockade for cancer therapy: current progress and perspectives[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300492

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author="Hongying YE, Weijie LIAO, Jiongli PAN, Yin SHI, Qingqing WANG",
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year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300492"
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%A Hongying YE
%A Weijie LIAO
%A Jiongli PAN
%A Yin SHI
%A Qingqing WANG
%J Journal of Zhejiang University SCIENCE B
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doi="https://doi.org/10.1631/jzus.B2300492"

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A1 - Hongying YE
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A1 - Jiongli PAN
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A1 - Qingqing WANG
J0 - Journal of Zhejiang University Science B
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Abstract: 
The dysfunction of anti-tumor immune responses is crucial for cancer progression. Immune checkpoint blockade (ICB), which could potentiate T cell responses, is an effective strategy for the normalization of host anti-tumor immunity. In recent years, immune checkpoints, expressed on both tumor cells and immune cells, have been identified; some of them have exhibited potential druggability and have been approved by the Food and Drug Administration (FDA) for clinical treatments. However, the limited responses and immune-related adverse events (irAEs) cannot be ignored. This review outlines the development and applications of ICBs, potential strategies for overcoming resistance, and future directions for ICB-based cancer immunotherapy.

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