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Prediction of peritoneal free cancer cells in gastric cancer patients by magnetic resonance golden-angle radial sampling dynamic contrast-enhanced imaging
Affiliation(s):
The First Affiliated Hospital of Ningbo University, Ningbo 315000, China;
moreAffiliation(s): The First Affiliated Hospital of Ningbo University, Ningbo 315000, China; Ningbo Medical Center Lihuili Hospital, Ningbo 315100, China;
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Xueqing YIN, Xinzhong RUAN, Yongmeng ZHU, Yongfang YIN, Rui HUANG, Chao LIANG. Prediction of peritoneal free cancer cells in gastric cancer patients by magnetic resonance golden-angle radial sampling dynamic contrast-enhanced imaging[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300929
@article{title="Prediction of peritoneal free cancer cells in gastric cancer patients by magnetic resonance golden-angle radial sampling dynamic contrast-enhanced imaging", author="Xueqing YIN, Xinzhong RUAN, Yongmeng ZHU, Yongfang YIN, Rui HUANG, Chao LIANG", journal="Journal of Zhejiang University Science B", year="in press", publisher="Zhejiang University Press & Springer", doi="https://doi.org/10.1631/jzus.B2300929" }
%0 Journal Article %T Prediction of peritoneal free cancer cells in gastric cancer patients by magnetic resonance golden-angle radial sampling dynamic contrast-enhanced imaging %A Xueqing YIN %A Xinzhong RUAN %A Yongmeng ZHU %A Yongfang YIN %A Rui HUANG %A Chao LIANG %J Journal of Zhejiang University SCIENCE B %P %@ 1673-1581 %D in press %I Zhejiang University Press & Springer doi="https://doi.org/10.1631/jzus.B2300929"
TY - JOUR T1 - Prediction of peritoneal free cancer cells in gastric cancer patients by magnetic resonance golden-angle radial sampling dynamic contrast-enhanced imaging A1 - Xueqing YIN A1 - Xinzhong RUAN A1 - Yongmeng ZHU A1 - Yongfang YIN A1 - Rui HUANG A1 - Chao LIANG J0 - Journal of Zhejiang University Science B SP - EP - %@ 1673-1581 Y1 - in press PB - Zhejiang University Press & Springer ER - doi="https://doi.org/10.1631/jzus.B2300929"
Abstract: Objective: Peritoneal free cancer cells can negatively impact disease progression and patient outcomes in gastric cancer. This study aimed to investigate the feasibility of using magnetic resonance (MR) Golden-Angle Radial Sampling (GRASP) dynamic contrast-enhanced imaging to predict the presence of peritoneal free cancer cells in gastric cancer patients. Methods: All enrolled patients were consecutively divided into analysis and validation groups. Preoperative MRI scans and perfusion were performed in patients with gastric cancer undergoing surgery, and peritoneal lavage specimens were collected for examination. Based on the peritoneal lavage cytology (PLC) results, patients were divided into negative and positive lavage fluid group. The data collected included clinical and magnetic resonance information. A nomogram prediction model was constructed to predict the positive rate of peritoneal lavage fluid, and the validity of the model was verified based on data from the verification group. Results: There was no statistical difference between the proportion of PLC positive cases predicted by GRASP MR and the actual PLC test (χ2=7.26, P=0.95). MR Tumor (T) staging, tumor thickness, and perfusion parameter Tofts-Ketty model volume transfer constant (Ktrans) were independent predictors of positive peritoneal lavage fluid. The nomogram model featured a C-index of 0.785 and 0.742 for the modeling and validation groups, respectively. Conclusion: GRASP MR dynamic contrast-enhanced imaging could effectively predict peritoneal free cancer cells in gastric cancer patients. The nomogram model constructed using these predictors may help clinicians to better predict the risk of peritoneal free cancer cells being present in gastric cancer patients.
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