JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics

Author(s): Taida HUANG, Xiaonan GUO, Xiaomin HUANG, Chenju YI, Yihui CUI, Yiyan DONG
Affiliation(s): Department of Neurology and International Institutes of Medicine, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China; more
Corresponding email(s): yichj@mail.sysu.edu.cn, yihuicui@zju.edu.cn, yiyandong@zju.edu.cn
Key Words: Lateral habenula; Neural circuits; Aversion; Stress dynamics; Depression-like state; Head-to-head comparison

Share this article to： More <<< Previous Paper \|Next Paper >>>

Taida HUANG, Xiaonan GUO, Xiaomin HUANG, Chenju YI, Yihui CUI, Yiyan DONG. Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300933

@article{title="Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics",
author="Taida HUANG, Xiaonan GUO, Xiaomin HUANG, Chenju YI, Yihui CUI, Yiyan DONG",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2300933"
}

%0 Journal Article
%T Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics
%A Taida HUANG
%A Xiaonan GUO
%A Xiaomin HUANG
%A Chenju YI
%A Yihui CUI
%A Yiyan DONG
%J Journal of Zhejiang University SCIENCE B
%P
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2300933"

TY - JOUR
T1 - Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics
A1 - Taida HUANG
A1 - Xiaonan GUO
A1 - Xiaomin HUANG
A1 - Chenju YI
A1 - Yihui CUI
A1 - Yiyan DONG
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B2300933"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Stress has been considered as a major risk factor for depressive disorders, triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits. Among various regions across the brain, the lateral habenula (LHb) serves as a critical hub for processing aversive information during the dynamic process of stress accumulation, thus having been implicated in the pathogenesis of depression. LHb neurons integrate aversive valence conveyed by distinct upstream inputs, many of which selectively innervate the medial part (LHbM) or lateral part (LHbL) of LHb. LHb subregions also separately assign aversive valence via dissociable projections to the downstream targets in the midbrain which provides feedback loops. Despite these strides, the spatiotemporal dynamics of LHb-centric neural circuits remain elusive during the progression of depression-like state under stress. In this review, we attempt to describe a framework in which LHb orchestrates aversive valence via the input-output specific neuronal architecture. Notably, a physiological form of Hebbian plasticity in LHb under multiple stressors has been unveiled to incubate neuronal hyperactivity in an input-specific manner, which causally encodes chronic stress experience and drives depression onset. Collectively, the recent progress and future efforts in elucidating LHb circuits shed light on early interventions and circuit-specific antidepressant therapies.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

Open peer comments: Debate/Discuss/Question/Opinion

<1>

- Go to

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference