JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases

Author(s): Qihui ZHOU, Panpan CEN, Zhi CHEN, Jie JIN
Affiliation(s): Department of Infectious Diseases, The Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China; more
Corresponding email(s): jinjie0429@163.com, zjuchenzhi@zju.edu.cn
Key Words: Nrf2 signaling pathway; Mitophagy; Liver diseases

Share this article to： More <<< Previous Paper \|Next Paper >>>

Qihui ZHOU, Panpan CEN, Zhi CHEN, Jie JIN. Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2400053

@article{title="Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases",
author="Qihui ZHOU, Panpan CEN, Zhi CHEN, Jie JIN",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B2400053"
}

%0 Journal Article
%T Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases
%A Qihui ZHOU
%A Panpan CEN
%A Zhi CHEN
%A Jie JIN
%J Journal of Zhejiang University SCIENCE B
%P
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B2400053"

TY - JOUR
T1 - Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases
A1 - Qihui ZHOU
A1 - Panpan CEN
A1 - Zhi CHEN
A1 - Jie JIN
J0 - Journal of Zhejiang University Science B
SP -
EP -
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B2400053"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an intracellular transcription factor that helps protect against oxidative stress in different types of cells under pathological conditions. Mitochondria are vital organelles functioning in diverse metabolic processes in the body, including redox reactions, lipid metabolism and cell death. Mitophagy, a specific form of autophagy for damaged mitochondria, plays a critical role in the pathophysiology of liver diseases. In this review we explain in detail the roles of the Nrf2 signaling pathway and mitophagy, and the relationship between them, in various hepatic diseases (nonalcoholic fatty liver disease, viral hepatitis, alcoholic liver disease, drug-induced liver injury, autoimmune hepatitis, hepatic ischemia–reperfusion injury and liver cancer). We also offer some potential insights and treatments relevant to clinical applications.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

Open peer comments: Debate/Discuss/Question/Opinion

<1>

- Go to

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference