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On-line Access: 2024-07-12
Received: 2024-01-10
Revision Accepted: 2024-05-30
Crosschecked: 0000-00-00
Cited: 0
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A drug-loaded flexible substrate improves the performance of conformal cortical electrodes
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Rongrong Qin, Tian Li, Yifu Tan, Fanqi Sun, Yuhao Zhou, Ronghao Lv, Xiaoli You, Bowen Ji, Peng Li & Wei Huang. A drug-loaded flexible substrate improves the performance of conformal cortical electrodes[J]. Journal of Zhejiang University Science D, 2024, 7(4): 399-412.
@article{title="A drug-loaded flexible substrate improves the performance
of conformal cortical electrodes",
author="Rongrong Qin, Tian Li, Yifu Tan, Fanqi Sun, Yuhao Zhou, Ronghao Lv, Xiaoli You, Bowen Ji, Peng Li & Wei Huang",
journal="Journal of Zhejiang University Science D",
volume="7",
number="4",
pages="399-412",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-024-00299-x"
}
%0 Journal Article
%T A drug-loaded flexible substrate improves the performance
of conformal cortical electrodes
%A Rongrong Qin
%A Tian Li
%A Yifu Tan
%A Fanqi Sun
%A Yuhao Zhou
%A Ronghao Lv
%A Xiaoli You
%A Bowen Ji
%A Peng Li & Wei Huang
%J Journal of Zhejiang University SCIENCE D
%V 7
%N 4
%P 399-412
%@ 1869-1951
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-024-00299-x
TY - JOUR
T1 - A drug-loaded flexible substrate improves the performance
of conformal cortical electrodes
A1 - Rongrong Qin
A1 - Tian Li
A1 - Yifu Tan
A1 - Fanqi Sun
A1 - Yuhao Zhou
A1 - Ronghao Lv
A1 - Xiaoli You
A1 - Bowen Ji
A1 - Peng Li & Wei Huang
J0 - Journal of Zhejiang University Science D
VL - 7
IS - 4
SP - 399
EP - 412
%@ 1869-1951
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-024-00299-x
Abstract: Cortical electrodes are a powerful tool for the stimulation and/or recording of electrical activity in the nervous system.
However, the inevitable wound caused by surgical implantation of electrodes presents bacterial infection and inflammatory
reaction risks associated with foreign body exposure. Moreover, inflammation of the wound area can dramatically worsen
in response to bacterial infection. These consequences can not only lead to the failure of cortical electrode implantation but
also threaten the lives of patients. Herein, we prepared a hydrogel made of bacterial cellulose (BC), a flexible substrate for
cortical electrodes, and further loaded antibiotic tetracycline (TC) and the anti-inflammatory drug dexamethasone (DEX)
onto it. The encapsulated drugs can be released from the BC hydrogel and effectively inhibit the growth of Gram-negative
and Gram-positive bacteria. Next, therapeutic cortical electrodes were developed by integrating the drug-loaded BC hydrogel
and nine-channel serpentine arrays; these were used to record electrocorticography (ECoG) signals in a rat model. Due to the
controlled release of TC and DEX from the BC hydrogel substrate, therapeutic cortical electrodes can alleviate or prevent
symptoms associated with the bacterial infection and inflammation of brain tissue. This approach facilitates the development
of drug delivery electrodes for resolving complications caused by implantable electrodes.
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