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On-line Access: 2025-07-30
Received: 2024-10-28
Revision Accepted: 2025-02-26
Crosschecked: 0000-00-00
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Ultrasmall ruthenium nanoparticles with enhanced and tunable multienzyme-like activity for periodontitis treatment
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Yangjie Shao, Pengpeng Xue, Dongqi You, Mingjian Zhu, Zhouyang Qian, Bo Zhang, Shanbiao Liu, Peihua Lin, Zhichao Liu, Chaoying Zhang, Xinyue Hu, Yuan Xie, Menghan Xu, Daishun Ling, Fangyuan Li, Mengfei Yu. Ultrasmall ruthenium nanoparticles with enhanced and tunable multienzyme-like activity for periodontitis treatment[J]. Journal of Zhejiang University Science D, 2025, 8(4): 524542.
@article{title="Ultrasmall ruthenium nanoparticles with enhanced and tunable
multienzyme-like activity for periodontitis treatment",
author="Yangjie Shao, Pengpeng Xue, Dongqi You, Mingjian Zhu, Zhouyang Qian, Bo Zhang, Shanbiao Liu, Peihua Lin, Zhichao Liu, Chaoying Zhang, Xinyue Hu, Yuan Xie, Menghan Xu, Daishun Ling, Fangyuan Li, Mengfei Yu",
journal="Journal of Zhejiang University Science D",
volume="8",
number="4",
pages="524542",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400436"
}
%0 Journal Article
%T Ultrasmall ruthenium nanoparticles with enhanced and tunable
multienzyme-like activity for periodontitis treatment
%A Yangjie Shao
%A Pengpeng Xue
%A Dongqi You
%A Mingjian Zhu
%A Zhouyang Qian
%A Bo Zhang
%A Shanbiao Liu
%A Peihua Lin
%A Zhichao Liu
%A Chaoying Zhang
%A Xinyue Hu
%A Yuan Xie
%A Menghan Xu
%A Daishun Ling
%A Fangyuan Li
%A Mengfei Yu
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 4
%P 524542
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400436
TY - JOUR
T1 - Ultrasmall ruthenium nanoparticles with enhanced and tunable
multienzyme-like activity for periodontitis treatment
A1 - Yangjie Shao
A1 - Pengpeng Xue
A1 - Dongqi You
A1 - Mingjian Zhu
A1 - Zhouyang Qian
A1 - Bo Zhang
A1 - Shanbiao Liu
A1 - Peihua Lin
A1 - Zhichao Liu
A1 - Chaoying Zhang
A1 - Xinyue Hu
A1 - Yuan Xie
A1 - Menghan Xu
A1 - Daishun Ling
A1 - Fangyuan Li
A1 - Mengfei Yu
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 4
SP - 524542
EP -
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400436
Abstract: Periodontitis is an inflammatory disease caused by oxidative stress and initiated by bacterial infection. The endogenous en?
zyme system is dysfunctional in the periodontitis microenvironment. Currently, traditional clinical treatment cannot effi?
ciently eliminate bacteria or relieve inflammation. To address this issue, we developed ultrasmall ruthenium nanoparticles
(US-RuNPs) with multienzyme-like activity. Our results indicated that US-RuNPs with an amplified electric field had a supe?
rior photothermal effect to large-sized RuNPs. Thus, US-RuNPs, through photothermal therapy (PTT), acted as bacterial
lysozyme to eliminate planktonic pathogens and biofilms. In addition, the antioxidant enzyme-like activity of US-RuNPs
was greater than that of large-sized RuNPs, and US-RuNPs could scavenge intracellular reactive oxygen species (ROS) and
inhibit inflammation-related responses. More importantly, US-RuNPs demonstrated a satisfactory effect against periodontitis
in vivo due to their synergistic antibacterial activity through PTT and antioxidant effects even in deep sites, decreasing the
alveolar bone loss to root length ratio (ABL/RL) from 70.70% to 20.15% and increasing the collagen volume fraction from
16.88% to 57.64%. Thus, US-RuNPs with approximately 2 nm diameter, mimicking multienzyme activity, have great poten?
tial for the treatment of periodontitis.
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