
Yuhao Zhou. Reversible electroporation: controllably opening the cellular doorway[J]. Journal of Zhejiang University Science D, 2026, 9(3): 415 - 435.
@article{title="Reversible electroporation: controllably opening the cellular doorway",
author="Yuhao Zhou",
journal="Journal of Zhejiang University Science D",
volume="9",
number="3",
pages="415 - 435",
year="2026",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500504"
}
%0 Journal Article
%T Reversible electroporation: controllably opening the cellular doorway
%A Yuhao Zhou
%J Journal of Zhejiang University SCIENCE D
%V 9
%N 3
%P 415 - 435
%@ 1869-1951
%D 2026
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500504
TY - JOUR
T1 - Reversible electroporation: controllably opening the cellular doorway
A1 - Yuhao Zhou
J0 - Journal of Zhejiang University Science D
VL - 9
IS - 3
SP - 415
EP - 435
%@ 1869-1951
Y1 - 2026
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2500504
Abstract: reversible electroporation (RE) involves applying pulsed electric fields to briefly disrupt cell membrane channels, allowing molecular transfer while preserving cell viability. Advances in RE combined with micro- and nano-devices have improved efficiency and safety in cellular analysis and engineering, holding substantial promise for biological research and precision medicine. This review summarizes progress in RE technology, spanning underlying theoretical principles, practical implementation, and emerging applications. By integrating mechanistic insights with parameter assessment, we strengthen process understanding of RE to support further optimization. To clarify RE implementation strategies, we present advances in micro- and nano-devices based on varying electric field control approaches. Using these platforms, we examine improvements in intracellular analysis, cellular engineering, drug delivery, and cell sampling to illustrate state-of-the-art RE applications. Finally, we outline future directions and trends for RE systems aimed at molecular mechanism mapping and personalized precision medicine, emphasizing their increasing relevance in practical settings.The alternative text for this image may have been generated using AI.
CLC number:
On-line Access: 2026-05-01
Received: 2025-10-03
Revision Accepted: 2025-11-26
Crosschecked: 0000-00-00
Cited:
Clicked: 11
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